H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

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Background: The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. However, the relationships among these seemingly disparate functions remain obscure. Results: We mapped H2A.Z genome-wide in mammalian ES cells and neural progenitor...

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Bibliographic Details
Main Authors: Ku, Manching, Jaffe, Jacob D., Koche, Richard Patrick, Rheinbay, Esther, Endoh, Mitsuhiro, Koseki, Haruhiko, Carr, Steven A., Bernstein, Bradley E.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Biomed Central Ltd. 2013
Online Access:http://hdl.handle.net/1721.1/76688

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