Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1

Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1

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Tyr142, the C-terminal amino acid of histone variant H2A.X is phosphorylated by WSTF (Williams-Beuren syndrome transcription factor), a component of the WICH complex (WSTF-ISWI chromatin-remodeling complex), under basal conditions in the cell. In response to DNA double-strand breaks (DSBs), H2A.X is...

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Bibliographic Details
Main Authors: Singh, Namit, Basnet, Harihar, Wiltshire, Timothy D., Mohammad, Duaa H., Thompson, James R., Heroux, Annie, Botuyan, Maria Victoria, Couch, Fergus J., Rosenfeld, Michael G., Mer, Georges, Yaffe, Michael B
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/76759
https://orcid.org/0000-0002-9547-3251

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