Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans
The genetic analysis of mechanisms of pathogen resistance in the nematode Caenorhabditis elegans has revealed a role for evolutionarily conserved signaling pathways that are required for innate immunity in a wide range of organisms, from worms to mammals. C. elegans represents one of the more simple...
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| Format: | Article |
| Language: | en_US |
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Company of Biologists
2013
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| Online Access: | http://hdl.handle.net/1721.1/76794 https://orcid.org/0000-0002-4109-5152 |
| _version_ | 1826200657117315072 |
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| author | Kim, Dennis H. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kim, Dennis H. |
| author_sort | Kim, Dennis H. |
| collection | MIT |
| description | The genetic analysis of mechanisms of pathogen resistance in the nematode Caenorhabditis elegans has revealed a role for evolutionarily conserved signaling pathways that are required for innate immunity in a wide range of organisms, from worms to mammals. C. elegans represents one of the more simple host organisms in which mechanisms of host defense can be dissected, and the use of C. elegans presents the researcher with a wide array of genetic and genomic tools to probe the host-pathogen interface. The study of host defense mechanisms in C. elegans continues to provide an ancient evolutionary perspective on innate immunity, which may generate insights into the conserved processes in phylogenetically diverse host organisms, including humans. |
| first_indexed | 2024-09-23T11:39:49Z |
| format | Article |
| id | mit-1721.1/76794 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:39:49Z |
| publishDate | 2013 |
| publisher | Company of Biologists |
| record_format | dspace |
| spelling | mit-1721.1/767942022-09-27T21:05:23Z Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans Kim, Dennis H. Massachusetts Institute of Technology. Department of Biology Kim, Dennis H. The genetic analysis of mechanisms of pathogen resistance in the nematode Caenorhabditis elegans has revealed a role for evolutionarily conserved signaling pathways that are required for innate immunity in a wide range of organisms, from worms to mammals. C. elegans represents one of the more simple host organisms in which mechanisms of host defense can be dissected, and the use of C. elegans presents the researcher with a wide array of genetic and genomic tools to probe the host-pathogen interface. The study of host defense mechanisms in C. elegans continues to provide an ancient evolutionary perspective on innate immunity, which may generate insights into the conserved processes in phylogenetically diverse host organisms, including humans. 2013-02-13T15:57:05Z 2013-02-13T15:57:05Z 2008-12 Article http://purl.org/eprint/type/JournalArticle 1754-8403 1754-8411 http://hdl.handle.net/1721.1/76794 Kim, D. “Studying Host-pathogen Interactions and Innate Immunity in Caenorhabditis Elegans.” Disease Models and Mechanisms 1.4-5 (2008): 205–208. Copyright © 2008 Published by The Company of Biologists Ltd https://orcid.org/0000-0002-4109-5152 en_US http://dx.doi.org/10.1242/dmm.000265 Disease Models and Mechanisms Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Company of Biologists Company of Biologists |
| spellingShingle | Kim, Dennis H. Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans |
| title | Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans |
| title_full | Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans |
| title_fullStr | Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans |
| title_full_unstemmed | Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans |
| title_short | Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans |
| title_sort | studying host pathogen interactions and innate immunity in caenorhabditis elegans |
| url | http://hdl.handle.net/1721.1/76794 https://orcid.org/0000-0002-4109-5152 |
| work_keys_str_mv | AT kimdennish studyinghostpathogeninteractionsandinnateimmunityincaenorhabditiselegans |