Replication–transcription conflicts in bacteria
DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major a...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2013
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| Online Access: | http://hdl.handle.net/1721.1/77912 https://orcid.org/0000-0002-8235-7227 |
| _version_ | 1811087356668674048 |
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| author | Merrikh, Houra Zhang, Yan Wang, Jue D. Grossman, Alan Davis |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Merrikh, Houra Zhang, Yan Wang, Jue D. Grossman, Alan Davis |
| author_sort | Merrikh, Houra |
| collection | MIT |
| description | DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major advances have been made in understanding how cells avoid conflicts between replication and transcription and how such conflicts are resolved when they do occur. In this Review, we summarize these findings, which shed light on the significance of the problem and on how bacterial cells deal with unwanted encounters between the replication and transcription machineries. |
| first_indexed | 2024-09-23T13:44:47Z |
| format | Article |
| id | mit-1721.1/77912 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:44:47Z |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/779122022-09-28T15:51:23Z Replication–transcription conflicts in bacteria Merrikh, Houra Zhang, Yan Wang, Jue D. Grossman, Alan Davis Massachusetts Institute of Technology. Department of Biology Grossman, Alan D. Grossman, Alan D. DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major advances have been made in understanding how cells avoid conflicts between replication and transcription and how such conflicts are resolved when they do occur. In this Review, we summarize these findings, which shed light on the significance of the problem and on how bacterial cells deal with unwanted encounters between the replication and transcription machineries. National Institutes of Health (U.S.) (grant GM084003) National Institutes of Health (U.S.) (grant GM41934) National Institutes of Health (U.S.) (postdoctoral fellowship GM093408) University of Washington. Department of Microbiology Cancer Prevention and Research Institute of Texas (Training Program grant RP101499) 2013-03-15T17:54:35Z 2013-03-15T17:54:35Z 2012-07 Article http://purl.org/eprint/type/JournalArticle 1740-1526 1740-1534 http://hdl.handle.net/1721.1/77912 Merrikh, Houra et al. “Replication–transcription Conflicts in Bacteria.” Nature Reviews Microbiology (2012): p.449-458. CrossRef. Web. https://orcid.org/0000-0002-8235-7227 en_US http://dx.doi.org/10.1038/nrmicro2800 Nature Reviews. Microbiology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group Grossman via Courtney Crummett |
| spellingShingle | Merrikh, Houra Zhang, Yan Wang, Jue D. Grossman, Alan Davis Replication–transcription conflicts in bacteria |
| title | Replication–transcription conflicts in bacteria |
| title_full | Replication–transcription conflicts in bacteria |
| title_fullStr | Replication–transcription conflicts in bacteria |
| title_full_unstemmed | Replication–transcription conflicts in bacteria |
| title_short | Replication–transcription conflicts in bacteria |
| title_sort | replication transcription conflicts in bacteria |
| url | http://hdl.handle.net/1721.1/77912 https://orcid.org/0000-0002-8235-7227 |
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