Evolving a robust signal transduction pathway from weak cross-talk

Evolving a robust signal transduction pathway from weak cross-talk

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We have evolved a robust two-component signal transduction pathway from a sensor kinase (SK) and non-partner response regulator (RR) that show weak cross-talk in vitro and no detectable cross-talk in vivo in wild-type strains. The SK, CpxA, is bifunctional, with both kinase and phosphatase activitie...

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Bibliographic Details
Main Authors:	Siryaporn, Albert, Perchuk, Barrett, Laub, Michael T
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	Nature Publishing Group 2013
Online Access:	http://hdl.handle.net/1721.1/78000 https://orcid.org/0000-0002-8288-7607

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