On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery
Performances of surface biosensors are often controlled by the analyte delivery rate to the sensing surface instead of sensors intrinsic detection capabilities. In a microfluidic channel, analyte transports diffusively to the biosensor surface severely limiting its performance. At low concentrations...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
SPIE
2013
|
| Online Access: | http://hdl.handle.net/1721.1/78001 |
| _version_ | 1826191286917398528 |
|---|---|
| author | Yanik, Ahmet Ali Huang, Min Artar, Alp Chang, Tsung-Yao Altug, Hatice |
| author2 | Massachusetts Institute of Technology. Research Laboratory of Electronics |
| author_facet | Massachusetts Institute of Technology. Research Laboratory of Electronics Yanik, Ahmet Ali Huang, Min Artar, Alp Chang, Tsung-Yao Altug, Hatice |
| author_sort | Yanik, Ahmet Ali |
| collection | MIT |
| description | Performances of surface biosensors are often controlled by the analyte delivery rate to the sensing surface instead of sensors intrinsic detection capabilities. In a microfluidic channel, analyte transports diffusively to the biosensor surface severely limiting its performance. At low concentrations, this limitation, commonly known as mass transport problem, causes impractically long detection times extending from days to months. In this proceeding, we propose and demonstrate a hybrid biosensing platform merging nanoplasmonics and nanofluidics. Unlike conventional approaches where the analytes simply stream pass over the sensing surface, our platform enables targeted delivery of analytes to the sensing surface. Our detection platform is based on extraordinary light transmission effect (EOT) in suspended plasmonic nanohole arrays. The subwavelength size nanoholes here act as nanofluidic channels connecting the microfluidic chambers on both sides of the sensors. In order to materialize our detection platform, we also introduce a novel multilayered micro/nanofluidics scheme allowing three dimensional control of the fluidic flow. Using our platform, we show 14-fold improvement in mass transport rate constant appearing in the exponential term. To fabricate these biosensors, we also introduce a lift-off free plasmonic device fabrication technique based on positive resist electron beam lithography. Simplicity of this fabrication technique allows us to fabricate nanostructures with ease, high yield/reproducibility and minimal surface roughness. As a result, we achieve higher refractive index sensitivities. This fabrication technique can find wide range of applications in nanoplasmonics field by eliminating the need for operationally slow and expensive focused ion beam lithography. |
| first_indexed | 2024-09-23T08:53:31Z |
| format | Article |
| id | mit-1721.1/78001 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:53:31Z |
| publishDate | 2013 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/780012022-09-30T11:56:24Z On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery Yanik, Ahmet Ali Huang, Min Artar, Alp Chang, Tsung-Yao Altug, Hatice Massachusetts Institute of Technology. Research Laboratory of Electronics Chang, Tsung-Yao Performances of surface biosensors are often controlled by the analyte delivery rate to the sensing surface instead of sensors intrinsic detection capabilities. In a microfluidic channel, analyte transports diffusively to the biosensor surface severely limiting its performance. At low concentrations, this limitation, commonly known as mass transport problem, causes impractically long detection times extending from days to months. In this proceeding, we propose and demonstrate a hybrid biosensing platform merging nanoplasmonics and nanofluidics. Unlike conventional approaches where the analytes simply stream pass over the sensing surface, our platform enables targeted delivery of analytes to the sensing surface. Our detection platform is based on extraordinary light transmission effect (EOT) in suspended plasmonic nanohole arrays. The subwavelength size nanoholes here act as nanofluidic channels connecting the microfluidic chambers on both sides of the sensors. In order to materialize our detection platform, we also introduce a novel multilayered micro/nanofluidics scheme allowing three dimensional control of the fluidic flow. Using our platform, we show 14-fold improvement in mass transport rate constant appearing in the exponential term. To fabricate these biosensors, we also introduce a lift-off free plasmonic device fabrication technique based on positive resist electron beam lithography. Simplicity of this fabrication technique allows us to fabricate nanostructures with ease, high yield/reproducibility and minimal surface roughness. As a result, we achieve higher refractive index sensitivities. This fabrication technique can find wide range of applications in nanoplasmonics field by eliminating the need for operationally slow and expensive focused ion beam lithography. 2013-03-27T16:07:39Z 2013-03-27T16:07:39Z 2010-08 Article http://purl.org/eprint/type/JournalArticle 0277-786X http://hdl.handle.net/1721.1/78001 Yanik, Ahmet Ali et al. “On-chip Nanoplasmonic Biosensors with Actively Controlled Nanofluidic Surface Delivery.” Proceedings of SPIE--the International Society for Optical Engineering; v.7757 (2010). 775735–775735–6. ©2010 SPIE en_US http://dx.doi.org/10.1117/12.860815 Proceedings of SPIE--the International Society for Optical Engineering; v.7757 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Yanik, Ahmet Ali Huang, Min Artar, Alp Chang, Tsung-Yao Altug, Hatice On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery |
| title | On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery |
| title_full | On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery |
| title_fullStr | On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery |
| title_full_unstemmed | On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery |
| title_short | On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery |
| title_sort | on chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery |
| url | http://hdl.handle.net/1721.1/78001 |
| work_keys_str_mv | AT yanikahmetali onchipnanoplasmonicbiosensorswithactivelycontrollednanofluidicsurfacedelivery AT huangmin onchipnanoplasmonicbiosensorswithactivelycontrollednanofluidicsurfacedelivery AT artaralp onchipnanoplasmonicbiosensorswithactivelycontrollednanofluidicsurfacedelivery AT changtsungyao onchipnanoplasmonicbiosensorswithactivelycontrollednanofluidicsurfacedelivery AT altughatice onchipnanoplasmonicbiosensorswithactivelycontrollednanofluidicsurfacedelivery |