Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex

Recruitment of cofactors to specific DNA sites is integral for specificity in gene regulation. As a model system, we examined how targeting and transcriptional control of the sulfur metabolism genes in Saccharomyces cerevisiae is governed by recruitment of the transcriptional co-activator Met4. We d...

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Bibliographic Details
Main Authors: Siggers, Trevor, Duyzend, Michael H., Reddy, Jessica, Khan, Sidra, Bulyk, Martha L.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Nature Publishing Group 2013
Online Access:http://hdl.handle.net/1721.1/78006