Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering
Thesis (S.M.)--Harvard-MIT Program in Health Sciences and Technology, 2012.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2013
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| Online Access: | http://hdl.handle.net/1721.1/78244 |
| _version_ | 1811081688688623616 |
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| author | Tay, Pei Kun Richie |
| author2 | Neel Joshi. |
| author_facet | Neel Joshi. Tay, Pei Kun Richie |
| author_sort | Tay, Pei Kun Richie |
| collection | MIT |
| description | Thesis (S.M.)--Harvard-MIT Program in Health Sciences and Technology, 2012. |
| first_indexed | 2024-09-23T11:50:55Z |
| format | Thesis |
| id | mit-1721.1/78244 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:50:55Z |
| publishDate | 2013 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/782442019-04-11T03:54:46Z Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering Tay, Pei Kun Richie Neel Joshi. Harvard--MIT Program in Health Sciences and Technology. Harvard--MIT Program in Health Sciences and Technology. Harvard--MIT Program in Health Sciences and Technology. Thesis (S.M.)--Harvard-MIT Program in Health Sciences and Technology, 2012. Cataloged from PDF version of thesis. Includes bibliographical references (p. 27-30). Composite hydrogels find increasing use as biomaterials because the addition of a filler often improves on the material properties of the original matrix, or provides new optical, magnetic, conductive or bioactive functionalities not inherent to the hydrogel. In this work we synthesized nanocomposite gelatin methacrylate (GelMA) hydrogels that incorporate D,L-cyclic peptide nanotubes. These nanotubes are biocompatible, stiff and their physical and chemical properties can be tailored simply by changing the amino acid sequence of the peptide. We show that the nanotubes successfully integrated into the hydrogel matrix and provided some mechanical reinforcement, without affecting hydrogel porosity or hydration characteristics. We will be using this composite system as a platform for engineering hydrogels with unique physical and biological properties to the hydrogel, for application as biological scaffolds. by Pei Kun Richie Tay. S.M. 2013-03-28T18:27:12Z 2013-03-28T18:27:12Z 2012 2012 Thesis http://hdl.handle.net/1721.1/78244 830025901 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 30 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Harvard--MIT Program in Health Sciences and Technology. Tay, Pei Kun Richie Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering |
| title | Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering |
| title_full | Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering |
| title_fullStr | Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering |
| title_full_unstemmed | Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering |
| title_short | Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering |
| title_sort | synthesis of composite hydrogels incorporating d l cyclic peptide nanotubes as a platform for materials engineering |
| topic | Harvard--MIT Program in Health Sciences and Technology. |
| url | http://hdl.handle.net/1721.1/78244 |
| work_keys_str_mv | AT taypeikunrichie synthesisofcompositehydrogelsincorporatingdlcyclicpeptidenanotubesasaplatformformaterialsengineering |