Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells. Although it has been established that defects in mitochondrial respiration are not the cause of ca...
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| Format: | Article |
| Language: | en_US |
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Annual Reviews
2013
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| Online Access: | http://hdl.handle.net/1721.1/78654 https://orcid.org/0000-0002-6702-4192 |
| _version_ | 1826193932620398592 |
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| author | Vander Heiden, Matthew G. Lunt, Sophia Yunkyungkwon |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Vander Heiden, Matthew G. Lunt, Sophia Yunkyungkwon |
| author_sort | Vander Heiden, Matthew G. |
| collection | MIT |
| description | Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells. Although it has been established that defects in mitochondrial respiration are not the cause of cancer or aerobic glycolysis, the advantages of enhanced glycolysis in cancer remain controversial. Many cells ranging from microbes to lymphocytes use aerobic glycolysis during rapid proliferation, which suggests it may play a fundamental role in supporting cell growth. Here, we review how glycolysis contributes to the metabolic processes of dividing cells. We provide a detailed accounting of the biosynthetic requirements to construct a new cell and illustrate the importance of glycolysis in providing carbons to generate biomass. We argue that the major function of aerobic glycolysis is to maintain high levels of glycolytic intermediates to support anabolic reactions in cells, thus providing an explanation for why increased glucose metabolism is selected for in proliferating cells throughout nature. |
| first_indexed | 2024-09-23T09:47:34Z |
| format | Article |
| id | mit-1721.1/78654 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:47:34Z |
| publishDate | 2013 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | mit-1721.1/786542022-09-26T13:44:39Z Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation Vander Heiden, Matthew G. Lunt, Sophia Yunkyungkwon Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Vander Heiden, Matthew Vander Heiden, Matthew G. Lunt, Sophia Yunkyungkwon Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells. Although it has been established that defects in mitochondrial respiration are not the cause of cancer or aerobic glycolysis, the advantages of enhanced glycolysis in cancer remain controversial. Many cells ranging from microbes to lymphocytes use aerobic glycolysis during rapid proliferation, which suggests it may play a fundamental role in supporting cell growth. Here, we review how glycolysis contributes to the metabolic processes of dividing cells. We provide a detailed accounting of the biosynthetic requirements to construct a new cell and illustrate the importance of glycolysis in providing carbons to generate biomass. We argue that the major function of aerobic glycolysis is to maintain high levels of glycolytic intermediates to support anabolic reactions in cells, thus providing an explanation for why increased glucose metabolism is selected for in proliferating cells throughout nature. Burroughs Wellcome Fund Smith Family Foundation Starr Cancer Consortium Damon Runyon Cancer Research Foundation 2013-05-01T17:09:24Z 2013-05-01T17:09:24Z 2011-11 Article http://purl.org/eprint/type/JournalArticle 1081-0706 1081-0706 http://hdl.handle.net/1721.1/78654 Lunt, Sophia Y., and Matthew G. Vander Heiden. “Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation.” Annual Review of Cell and Developmental Biology 27.1 (2011): 441–464. https://orcid.org/0000-0002-6702-4192 en_US http://dx.doi.org/10.1146/annurev-cellbio-092910-154237 Annual Review of Cell and Developmental Biology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Annual Reviews Vander Heiden via Courtney Crummett |
| spellingShingle | Vander Heiden, Matthew G. Lunt, Sophia Yunkyungkwon Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation |
| title | Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation |
| title_full | Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation |
| title_fullStr | Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation |
| title_full_unstemmed | Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation |
| title_short | Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation |
| title_sort | aerobic glycolysis meeting the metabolic requirements of cell proliferation |
| url | http://hdl.handle.net/1721.1/78654 https://orcid.org/0000-0002-6702-4192 |
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