Tuning an activator-repressor clock employing retroactivity
Activator-repressor systems have been shown to be capable of oscillations and are therefore an important clock motif in the field of Synthetic and Systems Biology. In this paper, we propose a method to regulate oscillatory behavior in such systems by the addition of DNA binding sites for the pro...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Automatic Control Council
2013
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| Online Access: | http://hdl.handle.net/1721.1/78667 https://orcid.org/0000-0001-6472-8576 |
| _version_ | 1826208037570871296 |
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| author | Rosenberg, Alexander Jayanthi, Shridhar Del Vecchio, Domitilla |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Rosenberg, Alexander Jayanthi, Shridhar Del Vecchio, Domitilla |
| author_sort | Rosenberg, Alexander |
| collection | MIT |
| description | Activator-repressor systems have been shown to
be capable of oscillations and are therefore an important clock
motif in the field of Synthetic and Systems Biology. In this paper,
we propose a method to regulate oscillatory behavior in such
systems by the addition of DNA binding sites for the proteins
involved in the clock network. We show that the retroactivity
effect caused by this addition can effectively change the relative
timescales among the protein dynamics and impact the behavior
of the clock. We also employ root locus analysis to obtain a
graphical interpretation of the results. |
| first_indexed | 2024-09-23T13:59:27Z |
| format | Article |
| id | mit-1721.1/78667 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:59:27Z |
| publishDate | 2013 |
| publisher | American Automatic Control Council |
| record_format | dspace |
| spelling | mit-1721.1/786672022-10-01T18:22:37Z Tuning an activator-repressor clock employing retroactivity Rosenberg, Alexander Jayanthi, Shridhar Del Vecchio, Domitilla Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Mechanical Engineering Jayanthi, Shridhar Del Vecchio, Domitilla Activator-repressor systems have been shown to be capable of oscillations and are therefore an important clock motif in the field of Synthetic and Systems Biology. In this paper, we propose a method to regulate oscillatory behavior in such systems by the addition of DNA binding sites for the proteins involved in the clock network. We show that the retroactivity effect caused by this addition can effectively change the relative timescales among the protein dynamics and impact the behavior of the clock. We also employ root locus analysis to obtain a graphical interpretation of the results. 2013-05-01T21:08:21Z 2013-05-01T21:08:21Z 2010-06 Article http://purl.org/eprint/type/ConferencePaper 9781457700811 1457700816 1457700808 9781457700804 http://hdl.handle.net/1721.1/78667 Rosenberg, Alexander, Shridhar Jayanthi and Domitilla Del Vecchio. "Tuning an activator-repressor clock employing retroactivity" In 2011 American Control Conference on O'Farrell Street, San Francisco, CA, USA June 29 - July 01, 2011. Proceedings. IEEE. 2011. https://orcid.org/0000-0001-6472-8576 en_US http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5991401 Proceedings of the 2011 American Control Conference (ACC) Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf American Automatic Control Council MIT web domain |
| spellingShingle | Rosenberg, Alexander Jayanthi, Shridhar Del Vecchio, Domitilla Tuning an activator-repressor clock employing retroactivity |
| title | Tuning an activator-repressor clock employing retroactivity |
| title_full | Tuning an activator-repressor clock employing retroactivity |
| title_fullStr | Tuning an activator-repressor clock employing retroactivity |
| title_full_unstemmed | Tuning an activator-repressor clock employing retroactivity |
| title_short | Tuning an activator-repressor clock employing retroactivity |
| title_sort | tuning an activator repressor clock employing retroactivity |
| url | http://hdl.handle.net/1721.1/78667 https://orcid.org/0000-0001-6472-8576 |
| work_keys_str_mv | AT rosenbergalexander tuninganactivatorrepressorclockemployingretroactivity AT jayanthishridhar tuninganactivatorrepressorclockemployingretroactivity AT delvecchiodomitilla tuninganactivatorrepressorclockemployingretroactivity |