Functional anatomy of neural circuits regulating fear and extinction
The memory of fear extinction is context dependent: fear that is suppressed in one context readily renews in another. Understanding of the underlying neuronal circuits is, therefore, of considerable clinical relevance for anxiety disorders. Prefrontal cortical and hippocampal inputs to the amygdala...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2013
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| Online Access: | http://hdl.handle.net/1721.1/78855 |
| _version_ | 1826197918455955456 |
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| author | Sheng, Morgan Hwa-Tze Knapska, Ewelina Macias, Matylda Mikosz, Marta Nowak, Aleksandra Owczarek, Dorota Wawrzyniak, Marcin Pieprzyk, Marcelina Cymerman, Iwona A. Werka, Tomasz Maren, Stephen Jaworski, Jacek Kaczmarek, Leszek |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Sheng, Morgan Hwa-Tze Knapska, Ewelina Macias, Matylda Mikosz, Marta Nowak, Aleksandra Owczarek, Dorota Wawrzyniak, Marcin Pieprzyk, Marcelina Cymerman, Iwona A. Werka, Tomasz Maren, Stephen Jaworski, Jacek Kaczmarek, Leszek |
| author_sort | Sheng, Morgan Hwa-Tze |
| collection | MIT |
| description | The memory of fear extinction is context dependent: fear that is suppressed in one context readily renews in another. Understanding of the underlying neuronal circuits is, therefore, of considerable clinical relevance for anxiety disorders. Prefrontal cortical and hippocampal inputs to the amygdala have recently been shown to regulate the retrieval of fear memories, but the cellular organization of these projections remains unclear. By using anterograde tracing in a transgenic rat in which neurons express a dendritically-targeted PSD-95:Venus fusion protein under the control of a c-fos promoter, we found that, during the retrieval of extinction memory, the dominant input to active neurons in the lateral amygdala was from the infralimbic cortex, whereas the retrieval of fear memory was associated with greater hippocampal and prelimbic inputs. This pattern of retrieval-related afferent input was absent in the central nucleus of the amygdala. Our data show functional anatomy of neural circuits regulating fear and extinction, providing a framework for therapeutic manipulations of these circuits. |
| first_indexed | 2024-09-23T10:55:37Z |
| format | Article |
| id | mit-1721.1/78855 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:55:37Z |
| publishDate | 2013 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/788552022-10-01T00:00:18Z Functional anatomy of neural circuits regulating fear and extinction Sheng, Morgan Hwa-Tze Knapska, Ewelina Macias, Matylda Mikosz, Marta Nowak, Aleksandra Owczarek, Dorota Wawrzyniak, Marcin Pieprzyk, Marcelina Cymerman, Iwona A. Werka, Tomasz Maren, Stephen Jaworski, Jacek Kaczmarek, Leszek Picower Institute for Learning and Memory Sheng, Morgan Hwa-Tze The memory of fear extinction is context dependent: fear that is suppressed in one context readily renews in another. Understanding of the underlying neuronal circuits is, therefore, of considerable clinical relevance for anxiety disorders. Prefrontal cortical and hippocampal inputs to the amygdala have recently been shown to regulate the retrieval of fear memories, but the cellular organization of these projections remains unclear. By using anterograde tracing in a transgenic rat in which neurons express a dendritically-targeted PSD-95:Venus fusion protein under the control of a c-fos promoter, we found that, during the retrieval of extinction memory, the dominant input to active neurons in the lateral amygdala was from the infralimbic cortex, whereas the retrieval of fear memory was associated with greater hippocampal and prelimbic inputs. This pattern of retrieval-related afferent input was absent in the central nucleus of the amygdala. Our data show functional anatomy of neural circuits regulating fear and extinction, providing a framework for therapeutic manipulations of these circuits. 2013-05-09T20:04:22Z 2013-05-09T20:04:22Z 2012-10 2012-02 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/78855 Knapska, E. et al. “Functional Anatomy of Neural Circuits Regulating Fear and Extinction.” Proceedings of the National Academy of Sciences 109.42 (2012): 17093–17098. ©2013 National Academy of Sciences en_US http://dx.doi.org/10.1073/pnas.1202087109 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Sheng, Morgan Hwa-Tze Knapska, Ewelina Macias, Matylda Mikosz, Marta Nowak, Aleksandra Owczarek, Dorota Wawrzyniak, Marcin Pieprzyk, Marcelina Cymerman, Iwona A. Werka, Tomasz Maren, Stephen Jaworski, Jacek Kaczmarek, Leszek Functional anatomy of neural circuits regulating fear and extinction |
| title | Functional anatomy of neural circuits regulating fear and extinction |
| title_full | Functional anatomy of neural circuits regulating fear and extinction |
| title_fullStr | Functional anatomy of neural circuits regulating fear and extinction |
| title_full_unstemmed | Functional anatomy of neural circuits regulating fear and extinction |
| title_short | Functional anatomy of neural circuits regulating fear and extinction |
| title_sort | functional anatomy of neural circuits regulating fear and extinction |
| url | http://hdl.handle.net/1721.1/78855 |
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