Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels
Author Manuscript date: 2011 June 27
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2013
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| Online Access: | http://hdl.handle.net/1721.1/78861 https://orcid.org/0000-0003-0588-9286 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826193955185754112 |
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| author | Rhee, Minsoung Valencia, Pedro Miguel Rodriguez, Maria I. Langer, Robert Farokhzad, Omid C. Karnik, Rohit |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Rhee, Minsoung Valencia, Pedro Miguel Rodriguez, Maria I. Langer, Robert Farokhzad, Omid C. Karnik, Rohit |
| author_sort | Rhee, Minsoung |
| collection | MIT |
| description | Author Manuscript date: 2011 June 27 |
| first_indexed | 2024-09-23T09:47:55Z |
| format | Article |
| id | mit-1721.1/78861 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:47:55Z |
| publishDate | 2013 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/788612022-09-30T16:54:31Z Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels Rhee, Minsoung Valencia, Pedro Miguel Rodriguez, Maria I. Langer, Robert Farokhzad, Omid C. Karnik, Rohit Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Rhee, Minsoung Valencia, Pedro Miguel Rodriguez, Maria I. Langer, Robert Karnik, Rohit Author Manuscript date: 2011 June 27 A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable. David H. Koch (Prostate Cancer Foundation Award in Nanotherapeutics) National Institutes of Health (U.S.) (Grant CA119349) National Science Foundation (U.S.) (Graduate Research Fellowship) 2013-05-13T18:22:33Z 2013-05-13T18:22:33Z 2011-02 2010-12 Article http://purl.org/eprint/type/JournalArticle 0935-9648 1521-4095 http://hdl.handle.net/1721.1/78861 Rhee, Minsoung, Pedro M. Valencia, Maria I. Rodriguez, et al. 2011Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels. Advanced Materials 23(12): H79–H83. https://orcid.org/0000-0003-0588-9286 https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1002/adma.201004333 Advanced Materials Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Wiley Blackwell PubMed Central |
| spellingShingle | Rhee, Minsoung Valencia, Pedro Miguel Rodriguez, Maria I. Langer, Robert Farokhzad, Omid C. Karnik, Rohit Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels |
| title | Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels |
| title_full | Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels |
| title_fullStr | Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels |
| title_full_unstemmed | Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels |
| title_short | Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels |
| title_sort | synthesis of size tunable polymeric nanoparticles enabled by 3d hydrodynamic flow focusing in single layer microchannels |
| url | http://hdl.handle.net/1721.1/78861 https://orcid.org/0000-0003-0588-9286 https://orcid.org/0000-0003-4255-0492 |
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