α[subscript v]β[subscript 3] Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug
Targeted delivery of therapeutics to tumor neovasculature is potentially a powerful approach for selective cancer treatment. Integrins are heterodimeric transmembrane proteins involved in cell adhesion and cell signaling, and their expression is commonly upregulated in cancers and inflammatory disea...
Main Authors: | Graf, Nora, Bielenberg, Diane R., Kolishetti, Nagesh, Muus, Christoph, Banyard, Jacqueline, Farokhzad, Omid C., Lippard, Stephen J. |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society (ACS)
2013
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Online Access: | http://hdl.handle.net/1721.1/78874 https://orcid.org/0000-0002-2693-4982 |
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