Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support

Massive amounts of clinical data can now be collected by stand-alone or wearable monitors over extended periods of time. One key challenge is to convert the volumes of raw data into clinically relevant and actionable information, ideally in real-time. This becomes imperative especially in the domai...

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Main Authors: Gordhandas, Ankit, Heldt, Thomas, Verghese, George C.
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:en_US
Published: American Association for Artificial Intelligence 2013
Online Access:http://hdl.handle.net/1721.1/79056
https://orcid.org/0000-0002-5930-7694
https://orcid.org/0000-0002-2446-1499
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author Gordhandas, Ankit
Heldt, Thomas
Verghese, George C.
author2 Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
author_facet Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Gordhandas, Ankit
Heldt, Thomas
Verghese, George C.
author_sort Gordhandas, Ankit
collection MIT
description Massive amounts of clinical data can now be collected by stand-alone or wearable monitors over extended periods of time. One key challenge is to convert the volumes of raw data into clinically relevant and actionable information, ideally in real-time. This becomes imperative especially in the domain of wearable monitors, where power and memory constraints prevent continuous communication of raw, uncompressed data to a base station for a health care provider. We focus here on algorithmic approaches to extract clinically meaningful information from the electrocardiogram (ECG) in realtime. We use a curve-length transform to identify, and aggregate from beat to beat, physiologically relevant timing information, such as the onsets and offsets of P-waves, QRS complexes, and T-waves, along with their respective magnitudes. Each heartbeat is thus parametrized in terms of 12 variables. Assuming a nominal heart-rate of 70 beats per minute, and a sampling frequency of 250 Hz, each beat has approximately 215 samples. Reducing each beat to 12 samples thus gives an 18-fold compression. An exponentially-weighted sliding average of the identified morphological features over the preceding twenty beats is also stored. Whenever any feature deviates significantly from its stored weighted average, the algorithm registers an alarm and also retains the raw ECG data of the 5 beats immediately preceding and following the anomalous occurrence, for a later review by a clinician.
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spelling mit-1721.1/790562022-09-29T20:08:59Z Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support Gordhandas, Ankit Heldt, Thomas Verghese, George C. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Gordhandas, Ankit Heldt, Thomas Verghese, George C. Massive amounts of clinical data can now be collected by stand-alone or wearable monitors over extended periods of time. One key challenge is to convert the volumes of raw data into clinically relevant and actionable information, ideally in real-time. This becomes imperative especially in the domain of wearable monitors, where power and memory constraints prevent continuous communication of raw, uncompressed data to a base station for a health care provider. We focus here on algorithmic approaches to extract clinically meaningful information from the electrocardiogram (ECG) in realtime. We use a curve-length transform to identify, and aggregate from beat to beat, physiologically relevant timing information, such as the onsets and offsets of P-waves, QRS complexes, and T-waves, along with their respective magnitudes. Each heartbeat is thus parametrized in terms of 12 variables. Assuming a nominal heart-rate of 70 beats per minute, and a sampling frequency of 250 Hz, each beat has approximately 215 samples. Reducing each beat to 12 samples thus gives an 18-fold compression. An exponentially-weighted sliding average of the identified morphological features over the preceding twenty beats is also stored. Whenever any feature deviates significantly from its stored weighted average, the algorithm registers an alarm and also retains the raw ECG data of the 5 beats immediately preceding and following the anomalous occurrence, for a later review by a clinician. Texas Instruments Incorporated 2013-05-31T17:22:54Z 2013-05-31T17:22:54Z 2011-03 Article http://purl.org/eprint/type/ConferencePaper 9781577354963 1577354966 http://hdl.handle.net/1721.1/79056 Gordhandas, Ankit J., Thomas Heldt and George C. Verghese. "Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support." In Computational physiology: papers from the AAAI spring symposium, March 21 - 23, 2011, Stanford University, Stanford, California USA. Copyright c 2011, Association for the Advancement of Artificial Intelligence. https://orcid.org/0000-0002-5930-7694 https://orcid.org/0000-0002-2446-1499 en_US http://www.aaai.org/ocs/index.php/SSS/SSS11/paper/view/2493/2904 Computational Physiology: Papers from the AAAI 2011 Spring Symposium Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for Artificial Intelligence Verghese via Amy Stout
spellingShingle Gordhandas, Ankit
Heldt, Thomas
Verghese, George C.
Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support
title Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support
title_full Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support
title_fullStr Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support
title_full_unstemmed Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support
title_short Real-Time Extraction and Analysis of Key Morphological Features in the Electrocardiogram, for Data Compression and Clinical Decision Support
title_sort real time extraction and analysis of key morphological features in the electrocardiogram for data compression and clinical decision support
url http://hdl.handle.net/1721.1/79056
https://orcid.org/0000-0002-5930-7694
https://orcid.org/0000-0002-2446-1499
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