Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany
In our paper (1), we analyzed isolates from the Escherichia coli O104:H4 outbreaks in Germany and France in May to July 2011. We concluded that, although the German outbreak was larger, the German isolates represent a clade within the greater diversity of the French outbreak. We proposed several hyp...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2013
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| Online Access: | http://hdl.handle.net/1721.1/79083 |
| _version_ | 1826214178209136640 |
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| author | Grad, Y. H. Lipsitch, M. Griggs, Allison Haas, Brian J. Shea, T. P. McCowan, C. Montmayeur, A. FitzGerald, M. Wortman, J. R. Krogfelt, K. A. Bingen, E. Weill, F.-X. Tietze, E. Flieger, A. Nusbaum, Chad Birren, Bruce W. Hung, Deborah T. Hanage, W. P. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Grad, Y. H. Lipsitch, M. Griggs, Allison Haas, Brian J. Shea, T. P. McCowan, C. Montmayeur, A. FitzGerald, M. Wortman, J. R. Krogfelt, K. A. Bingen, E. Weill, F.-X. Tietze, E. Flieger, A. Nusbaum, Chad Birren, Bruce W. Hung, Deborah T. Hanage, W. P. |
| author_sort | Grad, Y. H. |
| collection | MIT |
| description | In our paper (1), we analyzed isolates from the Escherichia coli O104:H4 outbreaks in Germany and France in May to July 2011. We concluded that, although the German outbreak was larger, the German isolates represent a clade within the greater diversity of the French outbreak. We proposed several hypotheses to explain these findings, including that the lineage leading to the German outbreak went through a narrow bottleneck that purged diversity.
Guy et al. (2) report the genomes of eight additional E. coli O104:H4 isolates sampled from the German outbreak. By focusing on the numbers of SNPs in their samples, they suggest that the German outbreak is more diverse than we reported and is similar to the French outbreak.
In fact, Guy et al.’s data (2) strongly support our conclusion that the German outbreak represents a clade within the diversity … |
| first_indexed | 2024-09-23T16:01:19Z |
| format | Article |
| id | mit-1721.1/79083 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:01:19Z |
| publishDate | 2013 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/790832022-09-29T17:41:49Z Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany Grad, Y. H. Lipsitch, M. Griggs, Allison Haas, Brian J. Shea, T. P. McCowan, C. Montmayeur, A. FitzGerald, M. Wortman, J. R. Krogfelt, K. A. Bingen, E. Weill, F.-X. Tietze, E. Flieger, A. Nusbaum, Chad Birren, Bruce W. Hung, Deborah T. Hanage, W. P. Massachusetts Institute of Technology. Department of Biology Lander, Eric S. In our paper (1), we analyzed isolates from the Escherichia coli O104:H4 outbreaks in Germany and France in May to July 2011. We concluded that, although the German outbreak was larger, the German isolates represent a clade within the greater diversity of the French outbreak. We proposed several hypotheses to explain these findings, including that the lineage leading to the German outbreak went through a narrow bottleneck that purged diversity. Guy et al. (2) report the genomes of eight additional E. coli O104:H4 isolates sampled from the German outbreak. By focusing on the numbers of SNPs in their samples, they suggest that the German outbreak is more diverse than we reported and is similar to the French outbreak. In fact, Guy et al.’s data (2) strongly support our conclusion that the German outbreak represents a clade within the diversity … 2013-06-10T18:28:05Z 2013-06-10T18:28:05Z 2012-12 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/79083 Grad, Y. H., M. Lipsitch, A. D. Griggs, B. J. Haas, T. P. Shea, C. McCowan, A. Montmayeur, et al. Reply to Guy Et Al.: Support for a Bottleneck in the 2011 Escherichia Coli O104:H4 Outbreak in Germany. Proceedings of the National Academy of Sciences 109, no. 52 (December 26, 2012): E3629-E3630. en_US http://dx.doi.org/10.1073/pnas.1209419110 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Grad, Y. H. Lipsitch, M. Griggs, Allison Haas, Brian J. Shea, T. P. McCowan, C. Montmayeur, A. FitzGerald, M. Wortman, J. R. Krogfelt, K. A. Bingen, E. Weill, F.-X. Tietze, E. Flieger, A. Nusbaum, Chad Birren, Bruce W. Hung, Deborah T. Hanage, W. P. Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany |
| title | Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany |
| title_full | Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany |
| title_fullStr | Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany |
| title_full_unstemmed | Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany |
| title_short | Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany |
| title_sort | reply to guy et al support for a bottleneck in the 2011 escherichia coli o104 h4 outbreak in germany |
| url | http://hdl.handle.net/1721.1/79083 |
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