Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers
Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. Most biodegradable polymers suffer from a short half life due to rapid d...
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| Format: | Article |
| Language: | en_US |
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Landes Bioscience
2013
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| Online Access: | http://hdl.handle.net/1721.1/79421 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826202466332442624 |
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| author | Wang, Jane Bettinger, Christopher J. Langer, Robert Borenstein, Jeffrey T. |
| author2 | Charles Stark Draper Laboratory |
| author_facet | Charles Stark Draper Laboratory Wang, Jane Bettinger, Christopher J. Langer, Robert Borenstein, Jeffrey T. |
| author_sort | Wang, Jane |
| collection | MIT |
| description | Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. Most biodegradable polymers suffer from a short half life due to rapid degradation upon implantation, exceedingly high stiffness, and limited ability to functionalize the surface with chemical moieties. This work describes the fabrication of microfluidic networks from poly(ester amide), poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) (APS), a recently developed biodegradable elastomeric poly(ester amide). Microfluidic scaffolds constructed from APS exhibit a much lower Young’s Modulus and a significantly longer degradation half-life than those of previously reported systems. The device is fabricated using a modified replica-molding technique, which is rapid, inexpensive, reproducible, and scalable, making the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds. |
| first_indexed | 2024-09-23T12:07:55Z |
| format | Article |
| id | mit-1721.1/79421 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:07:55Z |
| publishDate | 2013 |
| publisher | Landes Bioscience |
| record_format | dspace |
| spelling | mit-1721.1/794212022-10-01T08:22:52Z Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers Wang, Jane Bettinger, Christopher J. Langer, Robert Borenstein, Jeffrey T. Charles Stark Draper Laboratory Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Program in Polymer Science and Technology Wang, Jane Bettinger, Christopher J. Borenstein, Jeffrey T. Langer, Robert Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. Most biodegradable polymers suffer from a short half life due to rapid degradation upon implantation, exceedingly high stiffness, and limited ability to functionalize the surface with chemical moieties. This work describes the fabrication of microfluidic networks from poly(ester amide), poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) (APS), a recently developed biodegradable elastomeric poly(ester amide). Microfluidic scaffolds constructed from APS exhibit a much lower Young’s Modulus and a significantly longer degradation half-life than those of previously reported systems. The device is fabricated using a modified replica-molding technique, which is rapid, inexpensive, reproducible, and scalable, making the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds. Charles Stark Draper Laboratory 2013-07-09T19:00:07Z 2013-07-09T19:00:07Z 2010-10 2010-06 Article http://purl.org/eprint/type/JournalArticle 1555-8592 1547-6278 http://hdl.handle.net/1721.1/79421 Wang, Jane, Christopher J. Bettinger, Robert S. Langer, and Jeffrey T. Borenstein 2010 Biodegradable Microfluidic Scaffolds for Tissue Engineering from Amino Alcohol-based Poly(ester Amide) Elastomers. Organogenesis 6(4): 212–216. https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.4161/org.6.4.12909 Organogenesis Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Landes Bioscience PMC |
| spellingShingle | Wang, Jane Bettinger, Christopher J. Langer, Robert Borenstein, Jeffrey T. Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers |
| title | Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers |
| title_full | Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers |
| title_fullStr | Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers |
| title_full_unstemmed | Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers |
| title_short | Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers |
| title_sort | biodegradable microfluidic scaffolds for tissue engineering from amino alcohol based poly ester amide elastomers |
| url | http://hdl.handle.net/1721.1/79421 https://orcid.org/0000-0003-4255-0492 |
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