Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2013.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2013
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| Online Access: | http://hdl.handle.net/1721.1/79558 |
| _version_ | 1826204371627540480 |
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| author | Kalcioglu, Zeynep Ilke |
| author2 | Krystyn J. Van Vliet. |
| author_facet | Krystyn J. Van Vliet. Kalcioglu, Zeynep Ilke |
| author_sort | Kalcioglu, Zeynep Ilke |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2013. |
| first_indexed | 2024-09-23T12:53:35Z |
| format | Thesis |
| id | mit-1721.1/79558 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T12:53:35Z |
| publishDate | 2013 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/795582019-04-11T00:01:48Z Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions Kalcioglu, Zeynep Ilke Krystyn J. Van Vliet. Massachusetts Institute of Technology. Department of Materials Science and Engineering. Massachusetts Institute of Technology. Department of Materials Science and Engineering. Materials Science and Engineering. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2013. Cataloged from PDF version of thesis. Includes bibliographical references (p. 157-168). Recent developments in computer-integrated surgery and in tissue-engineered constructs necessitate advances in experimental and analytical techniques in characterizing properties of mechanically compliant materials such as gels and soft tissues, particularly for small sample volumes. One goal of such developments is to quantitatively predict and mimic tissue deformation due to high rate impact events typical of industrial accidents and ballistic insults. This aim requires advances in mechanical characterization to establish tools and design principles for tissue simulant materials that can recapitulate the mechanical responses of hydrated soft tissues under dynamic contact-loading conditions. Given this motivation, this thesis studies the mechanical properties of compliant synthetic materials developed for tissue scaffold applications and of soft tissues, via modifying an established contact based technique for accurate, small scale characterization under fully hydrated conditions, and addresses some of the challenges in the implementation of this method. Two different engineered material systems composed of physically associating block copolymer gels, and chemically crosslinked networks including a solvent are presented as potential tissue simulants for ballistic applications, and compared directly to soft tissues from murine heart and liver. In addition to conventional quasistatic and dynamic bulk mechanical techniques that study macroscale elastic and viscoelastic properties, new methodologies are developed to study the small scale mechanical response of the aforementioned material systems to concentrated impact loading. The resistance to penetration and the energy dissipative constants are quantified in order to compare the deformation of soft tissues and mechanically optimized simulants, and to identify the underlying mechanisms by which the mechanical response of these tissue simulant candidates are modulated. Finally, given that soft tissues are biphasic in nature, atomic force microscopy enabled load relaxation experiments are utilized to develop approaches to distinguish between poroelastic and viscoelastic regimes, and to study how the anisotropy of the tissue structure affects elastic and transport properties, in order to inform the future design of tissue simulant gels that would mimic soft tissue response. by Zeynep Ilke Kalcioglu. Ph.D. 2013-07-10T14:54:32Z 2013-07-10T14:54:32Z 2013 2013 Thesis http://hdl.handle.net/1721.1/79558 851443455 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 178 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Materials Science and Engineering. Kalcioglu, Zeynep Ilke Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions |
| title | Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions |
| title_full | Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions |
| title_fullStr | Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions |
| title_full_unstemmed | Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions |
| title_short | Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions |
| title_sort | mechanical behavior of tissue simulants and soft tissues under extreme loading conditions |
| topic | Materials Science and Engineering. |
| url | http://hdl.handle.net/1721.1/79558 |
| work_keys_str_mv | AT kalciogluzeynepilke mechanicalbehavioroftissuesimulantsandsofttissuesunderextremeloadingconditions |