Macroporous nanowire nanoelectronic scaffolds for synthetic tissues
available in PMC 2013 April 11.
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2013
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| Online Access: | http://hdl.handle.net/1721.1/79576 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1811077513858777088 |
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| author | Tian, Bozhi Dvir, Tal Jin, Lihua Tsui, Jonathan H. Qing, Quan Suo, Zhigang Kohane, Daniel S. Lieber, Charles M. Liu, Jia, 1972- Langer, Robert S |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Tian, Bozhi Dvir, Tal Jin, Lihua Tsui, Jonathan H. Qing, Quan Suo, Zhigang Kohane, Daniel S. Lieber, Charles M. Liu, Jia, 1972- Langer, Robert S |
| author_sort | Tian, Bozhi |
| collection | MIT |
| description | available in PMC 2013 April 11. |
| first_indexed | 2024-09-23T10:44:13Z |
| format | Article |
| id | mit-1721.1/79576 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:44:13Z |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/795762022-09-30T22:36:35Z Macroporous nanowire nanoelectronic scaffolds for synthetic tissues Tian, Bozhi Dvir, Tal Jin, Lihua Tsui, Jonathan H. Qing, Quan Suo, Zhigang Kohane, Daniel S. Lieber, Charles M. Liu, Jia, 1972- Langer, Robert S Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Langer, Robert Tian, Bozhi Dvir, Tal available in PMC 2013 April 11. The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs. National Institutes of Health (U.S.) (Director’s Pioneer award) McKnight Foundation (Technological Innovations in Neurosciences Award) Boston Children's Hospital (Biotechnology Research Endowment) National Institutes of Health (U.S.) (DE013023) National Institutes of Health (U.S.) (DE016516) 2013-07-10T20:29:02Z 2013-07-10T20:29:02Z 2012-11 Article http://purl.org/eprint/type/JournalArticle 1476-1122 1476-4660 http://hdl.handle.net/1721.1/79576 Tian, Bozhi, Jia Liu, Tal Dvir, et al. 2012 Macroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissues. Nature Materials 11(11): 986–994. https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1038/nmat3404 Nature Materials Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Tian, Bozhi Dvir, Tal Jin, Lihua Tsui, Jonathan H. Qing, Quan Suo, Zhigang Kohane, Daniel S. Lieber, Charles M. Liu, Jia, 1972- Langer, Robert S Macroporous nanowire nanoelectronic scaffolds for synthetic tissues |
| title | Macroporous nanowire nanoelectronic scaffolds for synthetic tissues |
| title_full | Macroporous nanowire nanoelectronic scaffolds for synthetic tissues |
| title_fullStr | Macroporous nanowire nanoelectronic scaffolds for synthetic tissues |
| title_full_unstemmed | Macroporous nanowire nanoelectronic scaffolds for synthetic tissues |
| title_short | Macroporous nanowire nanoelectronic scaffolds for synthetic tissues |
| title_sort | macroporous nanowire nanoelectronic scaffolds for synthetic tissues |
| url | http://hdl.handle.net/1721.1/79576 https://orcid.org/0000-0003-4255-0492 |
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