Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

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Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon 1 of the HTT gene that translates to a polyglutamine tract in the huntingtin p...

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Bibliographic Details
Main Authors: Sathasivam, Kirupa, Neueder, Andreas, Landles, Christian, Benjamin, Agnesska C., Bondulich, Marie K., Amith, Donna L., Faull, Richard L. M., Roos, Raymund A. C., Howland, David, Detloff, Peter J., Bates, Gillian P., Housman, David E, Wasylenko, Theresa Anne
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/79814
https://orcid.org/0000-0002-0524-5301
https://orcid.org/0000-0001-5016-0756

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