Siderophore-based detection of Fe(iii) and microbial pathogens
Siderophores are low-molecular-weight iron chelators that are produced and exported by bacteria, fungi and plants during periods of nutrient deprivation. The structures, biosynthetic logic, and coordination chemistry of these molecules have fascinated chemists for decades. Studies of such fundamenta...
| Main Authors: | , |
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| Format: | Article |
| Language: | en_US |
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Royal Society of Chemistry, The
2013
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| Online Access: | http://hdl.handle.net/1721.1/79848 https://orcid.org/0000-0002-6153-8803 |
| _version_ | 1811087217451335680 |
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| author | Zheng, Tengfei Nolan, Elizabeth M. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Zheng, Tengfei Nolan, Elizabeth M. |
| author_sort | Zheng, Tengfei |
| collection | MIT |
| description | Siderophores are low-molecular-weight iron chelators that are produced and exported by bacteria, fungi and plants during periods of nutrient deprivation. The structures, biosynthetic logic, and coordination chemistry of these molecules have fascinated chemists for decades. Studies of such fundamental phenomena guide the use of siderophores and siderophore conjugates in a variety of medicinal applications that include iron-chelation therapies and drug delivery. Sensing applications constitute another important facet of siderophore-based technologies. The high affinities of siderophores for both ferric ions and siderophore receptors, proteins expressed on the cell surface that are required for ferric siderophore import, indicate that these small molecules may be employed for the selective capture of metal ions, proteins, and live bacteria. This minireview summaries progress in methods that utilize native bacterial and fungal siderophore scaffolds for the detection of Fe(III) or microbial pathogens. |
| first_indexed | 2024-09-23T13:41:56Z |
| format | Article |
| id | mit-1721.1/79848 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:41:56Z |
| publishDate | 2013 |
| publisher | Royal Society of Chemistry, The |
| record_format | dspace |
| spelling | mit-1721.1/798482022-09-28T15:36:44Z Siderophore-based detection of Fe(iii) and microbial pathogens Zheng, Tengfei Nolan, Elizabeth M. Massachusetts Institute of Technology. Department of Chemistry Nolan, Elizabeth M. Zheng, Tengfei Nolan, Elizabeth M. Siderophores are low-molecular-weight iron chelators that are produced and exported by bacteria, fungi and plants during periods of nutrient deprivation. The structures, biosynthetic logic, and coordination chemistry of these molecules have fascinated chemists for decades. Studies of such fundamental phenomena guide the use of siderophores and siderophore conjugates in a variety of medicinal applications that include iron-chelation therapies and drug delivery. Sensing applications constitute another important facet of siderophore-based technologies. The high affinities of siderophores for both ferric ions and siderophore receptors, proteins expressed on the cell surface that are required for ferric siderophore import, indicate that these small molecules may be employed for the selective capture of metal ions, proteins, and live bacteria. This minireview summaries progress in methods that utilize native bacterial and fungal siderophore scaffolds for the detection of Fe(III) or microbial pathogens. Massachusetts Institute of Technology. Dept. of Chemistry 2013-08-14T13:24:35Z 2013-08-14T13:24:35Z 2012-08 2012-05 Article http://purl.org/eprint/type/JournalArticle 1756-5901 1756-591X http://hdl.handle.net/1721.1/79848 Zheng, Tengfei, and Elizabeth M. Nolan. “Siderophore-based detection of Fe(iii) and microbial pathogens.” Metallomics 4, no. 9 (2012): 866. https://orcid.org/0000-0002-6153-8803 en_US http://dx.doi.org/ 10.1039/c2mt20082a Metallomics Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Royal Society of Chemistry, The Prof. Nolan via Erja Kajosalo |
| spellingShingle | Zheng, Tengfei Nolan, Elizabeth M. Siderophore-based detection of Fe(iii) and microbial pathogens |
| title | Siderophore-based detection of Fe(iii) and microbial pathogens |
| title_full | Siderophore-based detection of Fe(iii) and microbial pathogens |
| title_fullStr | Siderophore-based detection of Fe(iii) and microbial pathogens |
| title_full_unstemmed | Siderophore-based detection of Fe(iii) and microbial pathogens |
| title_short | Siderophore-based detection of Fe(iii) and microbial pathogens |
| title_sort | siderophore based detection of fe iii and microbial pathogens |
| url | http://hdl.handle.net/1721.1/79848 https://orcid.org/0000-0002-6153-8803 |
| work_keys_str_mv | AT zhengtengfei siderophorebaseddetectionoffeiiiandmicrobialpathogens AT nolanelizabethm siderophorebaseddetectionoffeiiiandmicrobialpathogens |