Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization
The synthesis of air-stable, highly water-soluble organic radicals containing a 1,3-bis(diphenylene)-2-phenylallyl (BDPA) core is reported. A sulfonated derivative, SA-BDPA, retains the narrow electron paramagnetic resonance linewidth (<30 MHz at 5 T) of the parent BDPA in highly concentrated gly...
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2013
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| Online Access: | http://hdl.handle.net/1721.1/79867 https://orcid.org/0000-0003-3097-6592 https://orcid.org/0000-0003-1589-832X |
| _version_ | 1826191576625315840 |
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| author | Haze, Olesya Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Haze, Olesya Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M |
| author_sort | Haze, Olesya |
| collection | MIT |
| description | The synthesis of air-stable, highly water-soluble organic radicals containing a 1,3-bis(diphenylene)-2-phenylallyl (BDPA) core is reported. A sulfonated derivative, SA-BDPA, retains the narrow electron paramagnetic resonance linewidth (<30 MHz at 5 T) of the parent BDPA in highly concentrated glycerol/water solutions (40 mM), which enables its use as polarizing agent for solid effect dynamic nuclear polarization (SE DNP). A sensitivity enhancement of 110 was obtained in high-field magic-angle-spinning (MAS) NMR experiments. The ease of synthesis and high maximum enhancements obtained with the BDPA-based radicals constitute a major advance over the trityl-type narrow-line polarization agents. |
| first_indexed | 2024-09-23T08:58:04Z |
| format | Article |
| id | mit-1721.1/79867 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:58:04Z |
| publishDate | 2013 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/798672022-09-26T09:30:31Z Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization Haze, Olesya Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M Massachusetts Institute of Technology. Department of Chemistry Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) Swager, Timothy M. Haze, Olesya Corzilius, Bjorn Smith, Albert A. Griffin, Robert Guy Swager, Timothy Manning The synthesis of air-stable, highly water-soluble organic radicals containing a 1,3-bis(diphenylene)-2-phenylallyl (BDPA) core is reported. A sulfonated derivative, SA-BDPA, retains the narrow electron paramagnetic resonance linewidth (<30 MHz at 5 T) of the parent BDPA in highly concentrated glycerol/water solutions (40 mM), which enables its use as polarizing agent for solid effect dynamic nuclear polarization (SE DNP). A sensitivity enhancement of 110 was obtained in high-field magic-angle-spinning (MAS) NMR experiments. The ease of synthesis and high maximum enhancements obtained with the BDPA-based radicals constitute a major advance over the trityl-type narrow-line polarization agents. National Institutes of Health (U.S.). (Grant GM095843) National Institutes of Health (U.S.). (Grant EB002804) National Institutes of Health (U.S.). (Grant EB002026) 2013-08-14T17:01:46Z 2013-08-14T17:01:46Z 2012-08 2012-05 Article http://purl.org/eprint/type/JournalArticle 0002-7863 1520-5126 http://hdl.handle.net/1721.1/79867 Haze, Olesya, Björn Corzilius, Albert A. Smith, Robert G. Griffin, and Timothy M. Swager. “Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization.” Journal of the American Chemical Society 134, no. 35 (September 5, 2012): 14287-14290. https://orcid.org/0000-0003-3097-6592 https://orcid.org/0000-0003-1589-832X en_US http://dx.doi.org/ 10.1021/ja304918g Journal of the American Chemical Society Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) Prof. Swager via Erja Kajosalo |
| spellingShingle | Haze, Olesya Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization |
| title | Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization |
| title_full | Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization |
| title_fullStr | Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization |
| title_full_unstemmed | Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization |
| title_short | Water-Soluble Narrow-Line Radicals for Dynamic Nuclear Polarization |
| title_sort | water soluble narrow line radicals for dynamic nuclear polarization |
| url | http://hdl.handle.net/1721.1/79867 https://orcid.org/0000-0003-3097-6592 https://orcid.org/0000-0003-1589-832X |
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