Conservation and divergence in the transcriptional programs of the human and mouse immune systems
Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2013
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| Online Access: | http://hdl.handle.net/1721.1/80383 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826206451144589312 |
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| author | Shay, Tal Jojic, Vladimir Zuk, Or Rothamel, Katherine Puyraimond-Zemmour, David Feng, Ting Wakamatsu, Ei Benoist, Christophe Koller, Daphne Regev, Aviv |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Shay, Tal Jojic, Vladimir Zuk, Or Rothamel, Katherine Puyraimond-Zemmour, David Feng, Ting Wakamatsu, Ei Benoist, Christophe Koller, Daphne Regev, Aviv |
| author_sort | Shay, Tal |
| collection | MIT |
| description | Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are conserved, particularly for lineage-specific genes. However, several hundred genes show clearly divergent expression across the examined cell lineages, and among them, 169 genes did so even with highly stringent criteria. Finally, regulatory mechanisms—reflected by regulators’ differential expression or enriched cis-elements—are conserved between the species but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses. |
| first_indexed | 2024-09-23T13:30:47Z |
| format | Article |
| id | mit-1721.1/80383 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:30:47Z |
| publishDate | 2013 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/803832022-09-28T14:35:01Z Conservation and divergence in the transcriptional programs of the human and mouse immune systems Shay, Tal Jojic, Vladimir Zuk, Or Rothamel, Katherine Puyraimond-Zemmour, David Feng, Ting Wakamatsu, Ei Benoist, Christophe Koller, Daphne Regev, Aviv Massachusetts Institute of Technology. Department of Biology Regev, Aviv Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are conserved, particularly for lineage-specific genes. However, several hundred genes show clearly divergent expression across the examined cell lineages, and among them, 169 genes did so even with highly stringent criteria. Finally, regulatory mechanisms—reflected by regulators’ differential expression or enriched cis-elements—are conserved between the species but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses. National Science Foundation (U.S.) (Grant DBI-034547) Howard Hughes Medical Institute Merkin Family Foundation for Stem Cell Research 2013-09-11T13:25:33Z 2013-09-11T13:25:33Z 2013-02 2013-01 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/80383 Shay, T., V. Jojic, O. Zuk, K. Rothamel, D. Puyraimond-Zemmour, T. Feng, E. Wakamatsu, C. Benoist, D. Koller, and A. Regev. “Conservation and divergence in the transcriptional programs of the human and mouse immune systems.” Proceedings of the National Academy of Sciences 110, no. 8 (February 19, 2013): 2946-2951. https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1073/pnas.1222738110 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Shay, Tal Jojic, Vladimir Zuk, Or Rothamel, Katherine Puyraimond-Zemmour, David Feng, Ting Wakamatsu, Ei Benoist, Christophe Koller, Daphne Regev, Aviv Conservation and divergence in the transcriptional programs of the human and mouse immune systems |
| title | Conservation and divergence in the transcriptional programs of the human and mouse immune systems |
| title_full | Conservation and divergence in the transcriptional programs of the human and mouse immune systems |
| title_fullStr | Conservation and divergence in the transcriptional programs of the human and mouse immune systems |
| title_full_unstemmed | Conservation and divergence in the transcriptional programs of the human and mouse immune systems |
| title_short | Conservation and divergence in the transcriptional programs of the human and mouse immune systems |
| title_sort | conservation and divergence in the transcriptional programs of the human and mouse immune systems |
| url | http://hdl.handle.net/1721.1/80383 https://orcid.org/0000-0001-8567-2049 |
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