Hepatic Stellate Cell–Targeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis

Hepatic Stellate Cell–Targeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis

Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate cells (HSCs) might improve treatment outcomes and reduce adverse effects on heal...

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Bibliographic Details
Main Authors: Narmada, Balakrishnan Chakrapani, Kang, Yuzhan, Venkatraman, Lakshmi, Peng, Qiwen, Sakban, Rashidah Binte, Nugraha, Bramasta, Jiang, Xuan, Bunte, Ralph M., So, Peter T.C., Tucker-Kellogg, Lisa, Mao, Hai-Quan, Yu, Hanry
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Mary Ann Liebert 2013
Online Access:http://hdl.handle.net/1721.1/80395
https://orcid.org/0000-0002-0339-3685
https://orcid.org/0000-0003-4698-6488

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