Monogenic, multigenic, and polygenic determinants of cancer risk
Thesis (S.M. in Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2002.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2005
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| Online Access: | http://hdl.handle.net/1721.1/8073 |
| _version_ | 1811092714893082624 |
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| author | Banava, Helen. |
| author2 | William G. Thilly. |
| author_facet | William G. Thilly. Banava, Helen. |
| author_sort | Banava, Helen. |
| collection | MIT |
| description | Thesis (S.M. in Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2002. |
| first_indexed | 2024-09-23T15:22:59Z |
| format | Thesis |
| id | mit-1721.1/8073 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T15:22:59Z |
| publishDate | 2005 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/80732019-04-12T14:35:29Z Monogenic, multigenic, and polygenic determinants of cancer risk Banava, Helen. William G. Thilly. Massachusetts Institute of Technology. Biological Engineering Division. Massachusetts Institute of Technology. Biological Engineering Division. Biological Engineering Division. Thesis (S.M. in Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2002. Includes bibliographical references (leaf 23, 1st group). A formal series of conditions of lifetime genetic risk of cancer is explored, and algebra is provided for applications in human population genetics. Risks are considered in terms of alleles necessary and/or sufficient for carcinogenesis. Alleles are first classified with respect to their effects on reproductive fitness, and then in terms of their potential effects on carcinogenic pathways. The algebraic formulations for a series of genetic possibilities: monogenic, multigenic, and polygenic, are provided. It is expected that technology will be developed to identify and enumerate rare inherited alleles in large general and cancer proband populations. by Helen Banava. S.M.in Toxicology 2005-08-24T20:07:11Z 2005-08-24T20:07:11Z 2002 2002 Thesis http://hdl.handle.net/1721.1/8073 51165964 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 25, [37] leaves 3034378 bytes 3034137 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biological Engineering Division. Banava, Helen. Monogenic, multigenic, and polygenic determinants of cancer risk |
| title | Monogenic, multigenic, and polygenic determinants of cancer risk |
| title_full | Monogenic, multigenic, and polygenic determinants of cancer risk |
| title_fullStr | Monogenic, multigenic, and polygenic determinants of cancer risk |
| title_full_unstemmed | Monogenic, multigenic, and polygenic determinants of cancer risk |
| title_short | Monogenic, multigenic, and polygenic determinants of cancer risk |
| title_sort | monogenic multigenic and polygenic determinants of cancer risk |
| topic | Biological Engineering Division. |
| url | http://hdl.handle.net/1721.1/8073 |
| work_keys_str_mv | AT banavahelen monogenicmultigenicandpolygenicdeterminantsofcancerrisk |