Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations
Colloidal particles placed in an energy landscape interact with each other, giving rise to complex dynamic behavior that affects the ability to process and manipulate suspensions of these particles. Propagating across scales ranging from the local behavior of 10's of particles to non-local beha...
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| Format: | Article |
| Language: | en_US |
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Royal Society of Chemistry, The
2013
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| Online Access: | http://hdl.handle.net/1721.1/80788 https://orcid.org/0000-0001-8898-2296 |
| _version_ | 1811080400467918848 |
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| author | Vahey, Michael D. Voldman, Joel |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Vahey, Michael D. Voldman, Joel |
| author_sort | Vahey, Michael D. |
| collection | MIT |
| description | Colloidal particles placed in an energy landscape interact with each other, giving rise to complex dynamic behavior that affects the ability to process and manipulate suspensions of these particles. Propagating across scales ranging from the local behavior of 10's of particles to non-local behavior encompassing >10[superscript 6] particles, these particle interactions are pervasive and challenging to describe quantitatively, especially in the confined environments typical of microfluidic devices. To better understand the effects of particle interactions in this context, we have performed experiments and simulations involving a simple microfluidic device in which hydrodynamic and electrostatic forces are leveraged to concentrate and separate particle mixtures. These investigations reveal the mechanisms underlying the dynamic patterns formed by micron-scale particles as they impinge on a dielectrophoretic force barrier: their tendency to aggregate and recirculate under constant operating conditions, and to reorganize when the operating conditions are changed. The emergent behaviors of these ensembles of interacting particles exhibit features of dynamical frustration and cooperativity that suggest non-intuitive strategies for concentrating and sorting suspensions. Finally, we present a simple analytic model based on hydrodynamic coupling that captures important features of strongly interacting particle suspensions. |
| first_indexed | 2024-09-23T11:31:03Z |
| format | Article |
| id | mit-1721.1/80788 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:31:03Z |
| publishDate | 2013 |
| publisher | Royal Society of Chemistry, The |
| record_format | dspace |
| spelling | mit-1721.1/807882022-09-27T20:02:49Z Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations Vahey, Michael D. Voldman, Joel Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Vahey, Michael D. Voldman, Joel Colloidal particles placed in an energy landscape interact with each other, giving rise to complex dynamic behavior that affects the ability to process and manipulate suspensions of these particles. Propagating across scales ranging from the local behavior of 10's of particles to non-local behavior encompassing >10[superscript 6] particles, these particle interactions are pervasive and challenging to describe quantitatively, especially in the confined environments typical of microfluidic devices. To better understand the effects of particle interactions in this context, we have performed experiments and simulations involving a simple microfluidic device in which hydrodynamic and electrostatic forces are leveraged to concentrate and separate particle mixtures. These investigations reveal the mechanisms underlying the dynamic patterns formed by micron-scale particles as they impinge on a dielectrophoretic force barrier: their tendency to aggregate and recirculate under constant operating conditions, and to reorganize when the operating conditions are changed. The emergent behaviors of these ensembles of interacting particles exhibit features of dynamical frustration and cooperativity that suggest non-intuitive strategies for concentrating and sorting suspensions. Finally, we present a simple analytic model based on hydrodynamic coupling that captures important features of strongly interacting particle suspensions. National Institutes of Health (U.S.) (Grant EB005753) National Science Foundation (U.S.). Instrument Development for Biological Research (Grant DBI-0852654) Singapore-MIT Alliance 2013-09-18T14:34:05Z 2013-09-18T14:34:05Z 2011 Article http://purl.org/eprint/type/JournalArticle 1473-0197 1473-0189 http://hdl.handle.net/1721.1/80788 Vahey, Michael D., and Joel Voldman. Emergent Behavior in Particle-laden Microfluidic Systems Informs Strategies for Improving Cell and Particle Separations. Lab on a Chip 11, no. 12 (2011): 2071. https://orcid.org/0000-0001-8898-2296 en_US http://dx.doi.org/10.1039/c0lc00602e Lab on a Chip Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Royal Society of Chemistry, The Voldman via Amy Stout |
| spellingShingle | Vahey, Michael D. Voldman, Joel Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations |
| title | Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations |
| title_full | Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations |
| title_fullStr | Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations |
| title_full_unstemmed | Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations |
| title_short | Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations |
| title_sort | emergent behavior in particle laden microfluidic systems informs strategies for improving cell and particle separations |
| url | http://hdl.handle.net/1721.1/80788 https://orcid.org/0000-0001-8898-2296 |
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