A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary – albeit often ineffective – treatment method, has remained largely unchanged over the past 50 years, highlighting th...

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Bibliographic Details
Main Authors: Schroeder, Frederick A., Lewis, Michael C., Fass, Daniel M., Wagner, Florence F., Zhang, Yan-Ling, Hennig, Krista M., Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D., Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L., Hooker, Jacob M., Holson, Edward B., Haggarty, Stephen J., Petryshen, Tracey
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:en_US
Published: Public Library of Science 2013
Online Access:http://hdl.handle.net/1721.1/81234

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