Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

Toxicity screening of compounds provides a means to identify compounds harmful for human health and the environment. Here, we further develop the technique of genomic phenotyping to improve throughput while maintaining specificity. We exposed cells to eight different compounds that rely on different...

Bibliografske podrobnosti
Main Authors:	Svensson, J. Peter, Quirós Pesudo, Laia, McRee, Siobhan K., Adeleye, Yeyejide A., Carmichael, Paul, Quiros Pesudo, Laia, Samson, Leona D
Drugi avtorji:	Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format:	Article
Jezik:	en_US
Izdano:	Public Library of Science 2013
Online dostop:	http://hdl.handle.net/1721.1/81239 https://orcid.org/0000-0002-7112-1454

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