Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
2011 December 2 Author's Manuscript
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Association for the Advancement of Science (AAAS)
2013
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| Online Access: | http://hdl.handle.net/1721.1/81244 https://orcid.org/0000-0003-1307-882X |
| _version_ | 1826211588974051328 |
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| author | Shulman, J. M. Parrado, A. Lindhagen-Persson, M. Reiman, E. M. Evans, D. A. Bennett, David A. Olofsson, A. De Jager, Philip L. Tanzi, R. E. Caldwell, Kim A. Caldwell, Guy A. Lindquist, Susan Treusch, Sebastian Hamamichi, Shusei Goodman, Jessica L. Matlack, Kent E. S. Chung, Chee Yeun Baru, Valeriya Valastyan, Julie Suzanne Han, Haesun Lindquist, Susan Bevis, Brooke J. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Shulman, J. M. Parrado, A. Lindhagen-Persson, M. Reiman, E. M. Evans, D. A. Bennett, David A. Olofsson, A. De Jager, Philip L. Tanzi, R. E. Caldwell, Kim A. Caldwell, Guy A. Lindquist, Susan Treusch, Sebastian Hamamichi, Shusei Goodman, Jessica L. Matlack, Kent E. S. Chung, Chee Yeun Baru, Valeriya Valastyan, Julie Suzanne Han, Haesun Lindquist, Susan Bevis, Brooke J. |
| author_sort | Shulman, J. M. |
| collection | MIT |
| description | 2011 December 2 Author's Manuscript |
| first_indexed | 2024-09-23T15:08:22Z |
| format | Article |
| id | mit-1721.1/81244 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:08:22Z |
| publishDate | 2013 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/812442022-10-02T00:49:55Z Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast Shulman, J. M. Parrado, A. Lindhagen-Persson, M. Reiman, E. M. Evans, D. A. Bennett, David A. Olofsson, A. De Jager, Philip L. Tanzi, R. E. Caldwell, Kim A. Caldwell, Guy A. Lindquist, Susan Treusch, Sebastian Hamamichi, Shusei Goodman, Jessica L. Matlack, Kent E. S. Chung, Chee Yeun Baru, Valeriya Valastyan, Julie Suzanne Han, Haesun Lindquist, Susan Bevis, Brooke J. Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Treusch, Sebastian Hamamichi, Shusei Goodman, Jessica L. Matlack, Kent E. S. Chung, Chee Yeun Baru, Valeriya Bevis, Brooke J. Valastyan, Julie Suzanne Han, Haesun Lindquist, Susan 2011 December 2 Author's Manuscript Aβ (beta-amyloid peptide) is an important contributor to Alzheimer’s disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD whose relationship to Aβ was previously unknown. The factors identified in yeast modified Aβ toxicity in glutamatergic neurons of Caenorhabditis elegans and in primary rat cortical neurons. In yeast, Aβ impaired the endocytic trafficking of a plasma membrane receptor, which was ameliorated by endocytic pathway factors identified in the yeast screen. Thus, links between Aβ, endocytosis, and human AD risk factors can be ascertained with yeast as a model system. Howard Hughes Medical Institute (Collaborative Innovation Award) National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service (Award Fellowship F32 NS067782-02) Cure Alzheimer’s Fund National Institutes of Health (U.S.) (Grant K08AG034290) National Institutes of Health (U.S.) (Grant P30AG10161) National Institutes of Health (U.S.) (Grant R01AG15819) National Institutes of Health (U.S.) (Grant R01AG17917) 2013-09-30T16:44:28Z 2013-09-30T16:44:28Z 2011-10 2011-08 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/81244 Treusch, S., S. Hamamichi, J. L. Goodman, K. E. S. Matlack, C. Y. Chung, V. Baru, J. M. Shulman, et al. “Functional Links Between A Toxicity, Endocytic Trafficking, and Alzheimer s Disease Risk Factors in Yeast.” Science 334, no. 6060 (December 1, 2011): 1241-1245. https://orcid.org/0000-0003-1307-882X en_US http://dx.doi.org/10.1126/science.1213210 Science Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) PubMed Central |
| spellingShingle | Shulman, J. M. Parrado, A. Lindhagen-Persson, M. Reiman, E. M. Evans, D. A. Bennett, David A. Olofsson, A. De Jager, Philip L. Tanzi, R. E. Caldwell, Kim A. Caldwell, Guy A. Lindquist, Susan Treusch, Sebastian Hamamichi, Shusei Goodman, Jessica L. Matlack, Kent E. S. Chung, Chee Yeun Baru, Valeriya Valastyan, Julie Suzanne Han, Haesun Lindquist, Susan Bevis, Brooke J. Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast |
| title | Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast |
| title_full | Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast |
| title_fullStr | Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast |
| title_full_unstemmed | Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast |
| title_short | Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast |
| title_sort | functional links between aβ toxicity endocytic trafficking and alzheimer s disease risk factors in yeast |
| url | http://hdl.handle.net/1721.1/81244 https://orcid.org/0000-0003-1307-882X |
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