Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells
Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Syn...
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science
2013
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| Online Access: | http://hdl.handle.net/1721.1/81267 |
| _version_ | 1826205654688202752 |
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| author | Pando, Bernardo Fabian Dong, Guogang Golden, Susan S. van Oudenaarden, Alexander Yang, Qiong, Ph. D. Massachusetts Institute of Technology |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Pando, Bernardo Fabian Dong, Guogang Golden, Susan S. van Oudenaarden, Alexander Yang, Qiong, Ph. D. Massachusetts Institute of Technology |
| author_sort | Pando, Bernardo Fabian |
| collection | MIT |
| description | Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows as a function of circadian and cell cycle phases. We infer that cell cycle progression in cyanobacteria slows during a specific circadian interval but is uniform across cell cycle phases. Our model is applicable to the quantification of the coupling between biological oscillators in other organisms. |
| first_indexed | 2024-09-23T13:16:31Z |
| format | Article |
| id | mit-1721.1/81267 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:16:31Z |
| publishDate | 2013 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | mit-1721.1/812672022-09-28T13:04:12Z Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells Pando, Bernardo Fabian Dong, Guogang Golden, Susan S. van Oudenaarden, Alexander Yang, Qiong, Ph. D. Massachusetts Institute of Technology Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Physics Yang, Qiong Pando, Bernardo Fabian van Oudenaarden, Alexander Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows as a function of circadian and cell cycle phases. We infer that cell cycle progression in cyanobacteria slows during a specific circadian interval but is uniform across cell cycle phases. Our model is applicable to the quantification of the coupling between biological oscillators in other organisms. National Science Foundation (U.S.) (NSF grant PHY-0548484) National Institutes of Health (U.S.) (NIH grant R01-GM068957) National Institutes of Health (U.S.) (NIH grant R01-GM062419) 2013-10-02T16:42:11Z 2013-10-02T16:42:11Z 2010-03 2009-09 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/81267 Yang, Q., B. F. Pando, G. Dong, S. S. Golden, and A. van Oudenaarden. “Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells.” Science 327, no. 5972 (March 18, 2010): 1522-1526. en_US http://dx.doi.org/10.1126/science.1181759 Science Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf American Association for the Advancement of Science PubMed Central |
| spellingShingle | Pando, Bernardo Fabian Dong, Guogang Golden, Susan S. van Oudenaarden, Alexander Yang, Qiong, Ph. D. Massachusetts Institute of Technology Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells |
| title | Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells |
| title_full | Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells |
| title_fullStr | Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells |
| title_full_unstemmed | Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells |
| title_short | Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells |
| title_sort | circadian gating of the cell cycle revealed in single cyanobacterial cells |
| url | http://hdl.handle.net/1721.1/81267 |
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