Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

Unlike normal tissues, cancers experience profound alterations in protein homeostasis. Powerful innate adaptive mechanisms, especially the transcriptional response regulated by Heat Shock Factor 1 (HSF1), are activated in cancers to enable survival under these stressful conditions. Natural products...

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Bibliographic Details
Main Authors: Santagata, Sandro, Xu, Ya-ming, Wijeratne, E. M. Kithsiri, Kontnik, Renee, Rooney, Christine, Perley, Casey C., Kwon, Hyoungtae, Clardy, Jon, Kesari, Santosh, Whitesell, Luke, Lindquist, Susan, Gunatilaka, A. A. Leslie
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2013
Online Access:http://hdl.handle.net/1721.1/81963
https://orcid.org/0000-0003-1307-882X

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