A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols
Forging a bond: An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols....
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2013
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| Online Access: | http://hdl.handle.net/1721.1/81973 https://orcid.org/0000-0003-3875-4775 |
| _version_ | 1826204747634311168 |
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| author | Wu, Xiaoxing Fors, Brett P. Buchwald, Stephen Leffler |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Wu, Xiaoxing Fors, Brett P. Buchwald, Stephen Leffler |
| author_sort | Wu, Xiaoxing |
| collection | MIT |
| description | Forging a bond: An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands. |
| first_indexed | 2024-09-23T13:00:45Z |
| format | Article |
| id | mit-1721.1/81973 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:00:45Z |
| publishDate | 2013 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/819732022-10-01T12:27:43Z A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols Wu, Xiaoxing Fors, Brett P. Buchwald, Stephen Leffler Massachusetts Institute of Technology. Department of Chemistry Wu, Xiaoxing Fors, Brett P. Buchwald, Stephen Leffler Forging a bond: An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands. National Institutes of Health (U.S.) (Grant GM-58160) Amgen Inc. Bristol-Myers Squibb Company (Graduate Fellowship) National Institutes of Health (U.S.) (GM 1S10RR13886-01) 2013-11-04T16:59:00Z 2013-11-04T16:59:00Z 2011-09 2011-06 Article http://purl.org/eprint/type/JournalArticle 14337851 1521-3773 http://hdl.handle.net/1721.1/81973 Wu, Xiaoxing, Brett P. Fors, and Stephen L. Buchwald. “A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols.” Angewandte Chemie International Edition 50, no. 42 (October 10, 2011): 9943-9947. https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1002/anie.201104361 Angewandte Chemie International Edition Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Wu, Xiaoxing Fors, Brett P. Buchwald, Stephen Leffler A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols |
| title | A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols |
| title_full | A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols |
| title_fullStr | A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols |
| title_full_unstemmed | A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols |
| title_short | A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols |
| title_sort | single phosphine ligand allows palladium catalyzed intermolecular c o bond formation with secondary and primary alcohols |
| url | http://hdl.handle.net/1721.1/81973 https://orcid.org/0000-0003-3875-4775 |
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