An Improved Synthesis of BrettPhos- and RockPhos-Type Biarylphosphine Ligands
Improved processes for the preparation of biphenyl-based phosphine ligands t-BuBrettPhos, RockPhos, and BrettPhos are presented. The new methods, featuring the use of Grignard reagents and catalytic amounts of copper, are superior to the previous methods, which require the use of tert-butyllithium a...
| Main Authors: | , |
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| Format: | Article |
| Language: | en_US |
| Published: |
Wiley Blackwell
2013
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| Online Access: | http://hdl.handle.net/1721.1/81975 https://orcid.org/0000-0003-3875-4775 |
| Summary: | Improved processes for the preparation of biphenyl-based phosphine ligands t-BuBrettPhos, RockPhos, and BrettPhos are presented. The new methods, featuring the use of Grignard reagents and catalytic amounts of copper, are superior to the previous methods, which require the use of tert-butyllithium and stoichiometric amounts of copper. Specifically, the use of less dangerous reagents provides a safer process, while the use of catalytic amounts of copper allows for the isolation of pure products in high yield. These improvements are particularly significant for the large-scale preparation of these ligands. |
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