Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots wa...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2013
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| Online Access: | http://hdl.handle.net/1721.1/81986 https://orcid.org/0000-0003-2220-4365 |
| _version_ | 1826202122641735680 |
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| author | Choi, Hak Soo Ipe, Binil Itty Misra, Preeti Lee, Jeong Heon Bawendi, Moungi G. Frangioni, John V. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Choi, Hak Soo Ipe, Binil Itty Misra, Preeti Lee, Jeong Heon Bawendi, Moungi G. Frangioni, John V. |
| author_sort | Choi, Hak Soo |
| collection | MIT |
| description | A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body. |
| first_indexed | 2024-09-23T12:02:13Z |
| format | Article |
| id | mit-1721.1/81986 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:02:13Z |
| publishDate | 2013 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/819862022-09-27T23:40:37Z Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots Choi, Hak Soo Ipe, Binil Itty Misra, Preeti Lee, Jeong Heon Bawendi, Moungi G. Frangioni, John V. Massachusetts Institute of Technology. Department of Chemistry Ipe, Binil Itty Bawendi, Moungi G. A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body. National Science Foundation (U.S.) (Massachusetts Institute of Technology. Biophysical Instrumentation Facility 0070319) National Institutes of Health (U.S.) (Massachusetts Institute of Technology. Biophysical Instrumentation Facility GM68762) National Institutes of Health (U.S.) (Grant R33-EB-000673) National Institutes of Health (U.S.) (MIT-Harvard NanoMedical Consortium U54-CA-119349) 2013-11-04T19:25:16Z 2013-11-04T19:25:16Z 2009-05 2009-04 Article http://purl.org/eprint/type/JournalArticle 1530-6984 1530-6992 http://hdl.handle.net/1721.1/81986 Choi, Hak Soo, Binil Itty Ipe, Preeti Misra, Jeong Heon Lee, Moungi G. Bawendi, and John V. Frangioni. “Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots.” Nano Letters 9, no. 6 (June 10, 2009): 2354-2359. https://orcid.org/0000-0003-2220-4365 en_US http://dx.doi.org/10.1021/nl900872r Nano Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Choi, Hak Soo Ipe, Binil Itty Misra, Preeti Lee, Jeong Heon Bawendi, Moungi G. Frangioni, John V. Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots |
| title | Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots |
| title_full | Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots |
| title_fullStr | Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots |
| title_full_unstemmed | Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots |
| title_short | Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots |
| title_sort | tissue and organ selective biodistribution of nir fluorescent quantum dots |
| url | http://hdl.handle.net/1721.1/81986 https://orcid.org/0000-0003-2220-4365 |
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