AFB1-induced mutagenesis of the gpt gene in AS52 cells
Aflatoxin B1 (AFB1) is a potent mutagen and an important risk factor for hepatocellular carcinoma (HCC) in humans. Transgenic mouse strains and cells in culture have been used to detect different types of mutations caused by AFB1 and investigate the molecular determinants of their location and frequ...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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John Wiley & Sons, Inc.
2013
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| Online Access: | http://hdl.handle.net/1721.1/82021 https://orcid.org/0000-0003-0771-9889 https://orcid.org/0000-0002-2196-5691 |
| _version_ | 1811094578536644608 |
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| author | Wattanawaraporn, Roongtiwa Kim, Min Young Adams, Jillian Trudel, Laura J. Woo, Leslie Croy, Robert G. Essigmann, John M. Wogan, Gerald N. |
| author2 | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
| author_facet | Massachusetts Institute of Technology. Center for Environmental Health Sciences Wattanawaraporn, Roongtiwa Kim, Min Young Adams, Jillian Trudel, Laura J. Woo, Leslie Croy, Robert G. Essigmann, John M. Wogan, Gerald N. |
| author_sort | Wattanawaraporn, Roongtiwa |
| collection | MIT |
| description | Aflatoxin B1 (AFB1) is a potent mutagen and an important risk factor for hepatocellular carcinoma (HCC) in humans. Transgenic mouse strains and cells in culture have been used to detect different types of mutations caused by AFB1 and investigate the molecular determinants of their location and frequency. The AFB1 mutational spectrum in the gpt gene was markedly different in AS52 cells compared with the liver in gpt delta B6C3F1 transgenic mice. The results demonstrate the importance of metabolism, chromosomal location, transcription and selection conditions on mutational spectra. |
| first_indexed | 2024-09-23T16:02:19Z |
| format | Article |
| id | mit-1721.1/82021 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:02:19Z |
| publishDate | 2013 |
| publisher | John Wiley & Sons, Inc. |
| record_format | dspace |
| spelling | mit-1721.1/820212022-10-02T05:50:55Z AFB1-induced mutagenesis of the gpt gene in AS52 cells Wattanawaraporn, Roongtiwa Kim, Min Young Adams, Jillian Trudel, Laura J. Woo, Leslie Croy, Robert G. Essigmann, John M. Wogan, Gerald N. Massachusetts Institute of Technology. Center for Environmental Health Sciences Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemistry Essigmann, John M. Essigmann, John M. Wattanawaraporn, Roongtiwa Kim, Min Young Adams, Jillian Trudel, Laura J. Woo, Leslie Croy, Robert G. Wogan, Gerald N. Aflatoxin B1 (AFB1) is a potent mutagen and an important risk factor for hepatocellular carcinoma (HCC) in humans. Transgenic mouse strains and cells in culture have been used to detect different types of mutations caused by AFB1 and investigate the molecular determinants of their location and frequency. The AFB1 mutational spectrum in the gpt gene was markedly different in AS52 cells compared with the liver in gpt delta B6C3F1 transgenic mice. The results demonstrate the importance of metabolism, chromosomal location, transcription and selection conditions on mutational spectra. National Institutes of Health (U.S.) (NIH grant R01 ES016313) National Institutes of Health (U.S.) (NIH grant P30 ES002109) National Institutes of Health (U.S.) (NIH grant T32 ES007020) Chulabhorn Research Institute (Bangkok, Thailand) 2013-11-07T18:08:33Z 2013-11-07T18:08:33Z 2012-08 2012-02 Article http://purl.org/eprint/type/JournalArticle 08936692 1098-2280 http://hdl.handle.net/1721.1/82021 Wattanawaraporn, Roongtiwa, Min Young Kim, Jillian Adams, Laura J. Trudel, Leslie L. Woo, Robert G. Croy, John M. Essigmann, and Gerald N. Wogan. “AFB1-induced mutagenesis of the gpt gene in AS52 cells.” Environmental and Molecular Mutagenesis 53, no. 7 (August 26, 2012): 567-573. https://orcid.org/0000-0003-0771-9889 https://orcid.org/0000-0002-2196-5691 en_US http://dx.doi.org/10.1002/em.21711 Environmental and Molecular Mutagenesis Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf John Wiley & Sons, Inc. Prof. Essigmann via Howard Silver |
| spellingShingle | Wattanawaraporn, Roongtiwa Kim, Min Young Adams, Jillian Trudel, Laura J. Woo, Leslie Croy, Robert G. Essigmann, John M. Wogan, Gerald N. AFB1-induced mutagenesis of the gpt gene in AS52 cells |
| title | AFB1-induced mutagenesis of the gpt gene in AS52 cells |
| title_full | AFB1-induced mutagenesis of the gpt gene in AS52 cells |
| title_fullStr | AFB1-induced mutagenesis of the gpt gene in AS52 cells |
| title_full_unstemmed | AFB1-induced mutagenesis of the gpt gene in AS52 cells |
| title_short | AFB1-induced mutagenesis of the gpt gene in AS52 cells |
| title_sort | afb1 induced mutagenesis of the gpt gene in as52 cells |
| url | http://hdl.handle.net/1721.1/82021 https://orcid.org/0000-0003-0771-9889 https://orcid.org/0000-0002-2196-5691 |
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