Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source
Plasmonic nanomaterials including gold nanorods are effective agents for inducing heating in tumors. Because near-infrared (NIR) light has traditionally been delivered using extracorporeal sources, most applications of plasmonic photothermal therapy have focused on isolated subcutaneous tumors. For...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2013
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| Online Access: | http://hdl.handle.net/1721.1/82087 https://orcid.org/0000-0002-0930-302X https://orcid.org/0000-0002-1293-2097 |
| _version_ | 1811068441589710848 |
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| author | Bagley, Alexander F. Hill, Samuel Rogers, Gary S. Bhatia, Sangeeta N. |
| author2 | Whitaker College of Health Sciences and Technology |
| author_facet | Whitaker College of Health Sciences and Technology Bagley, Alexander F. Hill, Samuel Rogers, Gary S. Bhatia, Sangeeta N. |
| author_sort | Bagley, Alexander F. |
| collection | MIT |
| description | Plasmonic nanomaterials including gold nanorods are effective agents for inducing heating in tumors. Because near-infrared (NIR) light has traditionally been delivered using extracorporeal sources, most applications of plasmonic photothermal therapy have focused on isolated subcutaneous tumors. For more complex models of disease such as advanced ovarian cancer, one of the primary barriers to gold nanorod-based strategies is the adequate delivery of NIR light to tumors located at varying depths within the body. To address this limitation, a series of implanted NIR illumination sources are described for the specific heating of gold nanorod-containing tissues. Through computational modeling and ex vivo studies, a candidate device is identified and validated in a model of orthotopic ovarian cancer. As the therapeutic, imaging, and diagnostic applications of plasmonic nanomaterials progress, effective methods for NIR light delivery to challenging anatomical regions will complement ongoing efforts to advance plasmonic photothermal therapy toward clinical use. |
| first_indexed | 2024-09-23T07:56:03Z |
| format | Article |
| id | mit-1721.1/82087 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T07:56:03Z |
| publishDate | 2013 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/820872022-09-23T09:43:45Z Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source Bagley, Alexander F. Hill, Samuel Rogers, Gary S. Bhatia, Sangeeta N. Whitaker College of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Bagley, Alexander F. Bhatia, Sangeeta N. Plasmonic nanomaterials including gold nanorods are effective agents for inducing heating in tumors. Because near-infrared (NIR) light has traditionally been delivered using extracorporeal sources, most applications of plasmonic photothermal therapy have focused on isolated subcutaneous tumors. For more complex models of disease such as advanced ovarian cancer, one of the primary barriers to gold nanorod-based strategies is the adequate delivery of NIR light to tumors located at varying depths within the body. To address this limitation, a series of implanted NIR illumination sources are described for the specific heating of gold nanorod-containing tissues. Through computational modeling and ex vivo studies, a candidate device is identified and validated in a model of orthotopic ovarian cancer. As the therapeutic, imaging, and diagnostic applications of plasmonic nanomaterials progress, effective methods for NIR light delivery to challenging anatomical regions will complement ongoing efforts to advance plasmonic photothermal therapy toward clinical use. National Institutes of Health (U.S.) (Medical Scientist Training Program) Harvard University. Biophysics Program 2013-11-12T16:22:54Z 2013-11-12T16:22:54Z 2013-08 2013-07 Article http://purl.org/eprint/type/JournalArticle 1936-0851 1936-086X http://hdl.handle.net/1721.1/82087 Bagley, Alexander F., Samuel Hill, Gary S. Rogers, and Sangeeta N. Bhatia. “Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source.” ACS Nano 7, no. 9 (September 24, 2013): 8089-8097. © 2013 American Chemical Society https://orcid.org/0000-0002-0930-302X https://orcid.org/0000-0002-1293-2097 en_US http://dx.doi.org/10.1021/nn4033757 ACS Nano Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Bagley, Alexander F. Hill, Samuel Rogers, Gary S. Bhatia, Sangeeta N. Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source |
| title | Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source |
| title_full | Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source |
| title_fullStr | Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source |
| title_full_unstemmed | Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source |
| title_short | Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source |
| title_sort | plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near infrared source |
| url | http://hdl.handle.net/1721.1/82087 https://orcid.org/0000-0002-0930-302X https://orcid.org/0000-0002-1293-2097 |
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