Tunable and Multifunctional Eukaryotic Transcription Factors Based on CRISPR/Cas
Transcriptional regulation is central to the complex behavior of natural biological systems and synthetic gene circuits. Platforms for the scalable, tunable, and simple modulation of transcription would enable new abilities to study natural systems and implement artificial capabilities in living cel...
Main Authors: | Farzadfard, Fahim, Perli, Samuel David, Lu, Timothy K |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society (ACS)
2013
|
Online Access: | http://hdl.handle.net/1721.1/82091 https://orcid.org/0000-0002-8346-2184 https://orcid.org/0000-0003-1389-8203 https://orcid.org/0000-0002-9999-6690 |
Similar Items
-
An integrated CRISPR-Cas toolkit for engineering human cells
by: Perli, Samuel David
Published: (2015) -
Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity
by: Chen, Ying-Chou, et al.
Published: (2021) -
Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells
by: Nissim, Lior, et al.
Published: (2016) -
RNA-based engineering of inducible CRISPR-Cas9 transcription factors for de novo assembly of eukaryotic gene circuits
by: Ferry, Q
Published: (2017) -
Rule-Based Design of Synthetic Transcription Factors in Eukaryotes
by: Purcell, Oliver, et al.
Published: (2016)