Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea

Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea

This study examined the gene transfer efficiency and toxicity of 2-kDa polyethylenimine conjugated to gold nanoparticles (PEI2-GNPs) in the human cornea in vitro and rabbit cornea in vivo. PEI2-GNPs with nitrogen-to-phosphorus ratios of up to 180 exhibited significant transgene delivery in the human...

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Bibliographic Details
Main Authors:	Sharma, Ajay, Tandon, Ashish, Tovey, Jonathan C.K., Gupta, Rangan, Robertson, J. David, Fortune, Jennifer A., Klibanov, Alexander M., Cowden, John W., Rieger, Frank G., Mohan, Rajiv R.
Other Authors:	Massachusetts Institute of Technology. Department of Biological Engineering
Format:	Article
Language:	en_US
Published:	Elsevier 2013
Online Access:	http://hdl.handle.net/1721.1/82126 https://orcid.org/0000-0003-3830-714X

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