Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors
The spectroscopic and proton- and Zn(II)-binding properties of two new members of the Zinpyr family of fluorescent sensors are reported. In ZP1B and ZP3B, a (2-picolyl)(4-picolyl)amine (2,4-DPA) moiety is installed in place of the di(2-picolyl)amine (2,2-DPA) ligand used in the parent sensors ZP1 an...
| Հիմնական հեղինակներ: | , , |
|---|---|
| Այլ հեղինակներ: | |
| Ձևաչափ: | Հոդված |
| Լեզու: | en_US |
| Հրապարակվել է: |
American Chemical Society (ACS)
2013
|
| Առցանց հասանելիություն: | http://hdl.handle.net/1721.1/82141 https://orcid.org/0000-0002-2693-4982 |
| _version_ | 1826199177027125248 |
|---|---|
| author | Wong, Brian A. Friedle, Simone Lippard, Stephen J. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Wong, Brian A. Friedle, Simone Lippard, Stephen J. |
| author_sort | Wong, Brian A. |
| collection | MIT |
| description | The spectroscopic and proton- and Zn(II)-binding properties of two new members of the Zinpyr family of fluorescent sensors are reported. In ZP1B and ZP3B, a (2-picolyl)(4-picolyl)amine (2,4-DPA) moiety is installed in place of the di(2-picolyl)amine (2,2-DPA) ligand used in the parent sensors ZP1 and ZP3. This modification has the benefit of both lowering the proton-induced turn-on at physiological pH levels and altering the Zn(II) affinity so as to detect only the most concentrated stores of this ion in biological samples. Comparison of the proton affinities of all four probes, as determined by potentiometric titrations, contributes to our understanding of the solution properties of this family of sensors. |
| first_indexed | 2024-09-23T11:15:57Z |
| format | Article |
| id | mit-1721.1/82141 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:15:57Z |
| publishDate | 2013 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/821412022-09-27T18:15:42Z Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors Wong, Brian A. Friedle, Simone Lippard, Stephen J. Massachusetts Institute of Technology. Department of Chemistry Wong, Brian A. Friedle, Simone Lippard, Stephen J. The spectroscopic and proton- and Zn(II)-binding properties of two new members of the Zinpyr family of fluorescent sensors are reported. In ZP1B and ZP3B, a (2-picolyl)(4-picolyl)amine (2,4-DPA) moiety is installed in place of the di(2-picolyl)amine (2,2-DPA) ligand used in the parent sensors ZP1 and ZP3. This modification has the benefit of both lowering the proton-induced turn-on at physiological pH levels and altering the Zn(II) affinity so as to detect only the most concentrated stores of this ion in biological samples. Comparison of the proton affinities of all four probes, as determined by potentiometric titrations, contributes to our understanding of the solution properties of this family of sensors. National Institute of General Medical Sciences (U.S.) (Grant GM065519) National Institutes of Health (U.S.) (Grant 1S10RR13886-01) 2013-11-15T19:24:18Z 2013-11-15T19:24:18Z 2009-07 2009-05 Article http://purl.org/eprint/type/JournalArticle 0020-1669 1520-510X http://hdl.handle.net/1721.1/82141 Wong, Brian A., Simone Friedle, and Stephen J. Lippard. “Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors.” Inorganic Chemistry 48, no. 15 (August 3, 2009): 7009-7011. https://orcid.org/0000-0002-2693-4982 en_US http://dx.doi.org/10.1021/ic900990w Inorganic Chemistry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Wong, Brian A. Friedle, Simone Lippard, Stephen J. Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors |
| title | Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors |
| title_full | Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors |
| title_fullStr | Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors |
| title_full_unstemmed | Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors |
| title_short | Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors |
| title_sort | subtle modification of 2 2 dipicolylamine lowers the affinity and improves the turn on of zn ii selective fluorescent sensors |
| url | http://hdl.handle.net/1721.1/82141 https://orcid.org/0000-0002-2693-4982 |
| work_keys_str_mv | AT wongbriana subtlemodificationof22dipicolylaminelowerstheaffinityandimprovestheturnonofzniiselectivefluorescentsensors AT friedlesimone subtlemodificationof22dipicolylaminelowerstheaffinityandimprovestheturnonofzniiselectivefluorescentsensors AT lippardstephenj subtlemodificationof22dipicolylaminelowerstheaffinityandimprovestheturnonofzniiselectivefluorescentsensors |