Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

A molecule that treats multiple age-related diseases would have a major impact on global health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target for drug design. Yet controversy exists around the mechanism of sirtuin-activating compounds (STACs). We found that spec...

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Bibliographic Details
Main Authors: Hubbard, B. P., Gomes, A. P., Dai, H., Li, J., Case, A. W., Considine, T., Riera, T. V., Lee, J. E., Yen, E. Sook, Lamming, D. W., Schuman, E. R., Stevens, L. A., Ling, A. J. Y., Armour, S. M., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S. M., Blum, C. A., Disch, J. S., Ng, Pui Yee, Howitz, K. T., Rolo, A. P., Hamuro, Y., Moss, Joel, Perni, R. B., Ellis, J. L., Vlasuk, G. P., Sinclair, D. A., Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2013
Online Access:http://hdl.handle.net/1721.1/82553

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