Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name sh...
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| Format: | Article |
| Language: | en_US |
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Springer-Verlag
2013
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| Online Access: | http://hdl.handle.net/1721.1/82622 https://orcid.org/0000-0002-3829-5612 |
| _version_ | 1826210106303315968 |
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| author | Cheeseman, Iain M |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Cheeseman, Iain M |
| author_sort | Cheeseman, Iain M |
| collection | MIT |
| description | The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres. |
| first_indexed | 2024-09-23T14:43:16Z |
| format | Article |
| id | mit-1721.1/82622 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:43:16Z |
| publishDate | 2013 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | mit-1721.1/826222022-10-01T22:08:49Z Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant Cheeseman, Iain M Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Cheeseman, Iain McPherson The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres. National Institutes of Health (U.S.) (Grant GM088313) 2013-12-02T18:57:19Z 2013-12-02T18:57:19Z 2013-04 2013-03 Article http://purl.org/eprint/type/JournalArticle 0967-3849 1573-6849 http://hdl.handle.net/1721.1/82622 Earnshaw, W. C., R. C. Allshire, B. E. Black, K. Bloom, B. R. Brinkley, W. Brown, I. M. Cheeseman, et al. “Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.” Chromosome Research 21, no. 2 (April 12, 2013): 101-106. https://orcid.org/0000-0002-3829-5612 en_US http://dx.doi.org/10.1007/s10577-013-9347-y Chromosome Research http://creativecommons.org/licenses/by/3.0/ application/pdf Springer-Verlag PMC |
| spellingShingle | Cheeseman, Iain M Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant |
| title | Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant |
| title_full | Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant |
| title_fullStr | Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant |
| title_full_unstemmed | Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant |
| title_short | Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant |
| title_sort | esperanto for histones cenp a not cenh3 is the centromeric histone h3 variant |
| url | http://hdl.handle.net/1721.1/82622 https://orcid.org/0000-0002-3829-5612 |
| work_keys_str_mv | AT cheesemaniainm esperantoforhistonescenpanotcenh3isthecentromerichistoneh3variant |