ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

A Disintegrin and Metalloproteinases (ADAMs) are the principal enzymes for shedding receptor tyrosine kinase (RTK) ectodomains and ligands from the cell surface. Multiple layers of activity regulation, feedback, and catalytic promiscuity impede our understanding of context-dependent ADAM “sheddase”...

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Bibliographic Details
Main Authors: Miller, Miles Aaron, Meyer, Aaron Samuel, Beste, Michael T., Lasisi, Zainab A., Reddy, Sonika N., Jeng, Karen, Griffith, Linda G., Lauffenburger, Douglas A., Chen, Chia-Hung, Han, Jongyoon, Isaacson, Keith B.
Other Authors: Massachusetts Institute of Technology. Center for Gynepathology Research
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/83378
https://orcid.org/0000-0002-1801-5548

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