Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP data from genome-wide studies, we imputed and teste...

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Bibliographic Details
Main Authors: Patsopoulos, Nikolaos A., Barcellos, Lisa F., Hintzen, Rogier Q., Schaefer, Catherine, van Duijn, Cornelia M., Noble, Janelle A., Raj, Towfique, Gourraud, Pierre-Antoine, Stranger, Barbara E., Oksenberg, Jorge, Olsson, Tomas, Taylor, Bruce V., Sawcer, Stephen, Hafler, David A., Carrington, Mary, De Jager, Philip L., de Bakker, Paul I. W.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Public Library of Science 2013
Online Access:http://hdl.handle.net/1721.1/83401

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