Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth
Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine...
| Main Authors: | , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2014
|
| Online Access: | http://hdl.handle.net/1721.1/83489 https://orcid.org/0000-0003-3214-4554 |
| _version_ | 1811068632085561344 |
|---|---|
| author | Zukerberg, Lawrence R Patrick, Gentry N Nikolic, Margareta Humbert, Sandrine Wu, Chin-Lee Vidal, Marc Van Etten, Richard A Tsai, Li-Huei Lanier, Lorene M. Gertler, Frank |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Zukerberg, Lawrence R Patrick, Gentry N Nikolic, Margareta Humbert, Sandrine Wu, Chin-Lee Vidal, Marc Van Etten, Richard A Tsai, Li-Huei Lanier, Lorene M. Gertler, Frank |
| author_sort | Zukerberg, Lawrence R |
| collection | MIT |
| description | Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of antisense Cables in primary cortical neurons inhibited neurite outgrowth. Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system. |
| first_indexed | 2024-09-23T07:58:49Z |
| format | Article |
| id | mit-1721.1/83489 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T07:58:49Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/834892022-09-30T01:27:03Z Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth Zukerberg, Lawrence R Patrick, Gentry N Nikolic, Margareta Humbert, Sandrine Wu, Chin-Lee Vidal, Marc Van Etten, Richard A Tsai, Li-Huei Lanier, Lorene M. Gertler, Frank Massachusetts Institute of Technology. Department of Biology Lanier, Lorene M. Gertler, Frank Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of antisense Cables in primary cortical neurons inhibited neurite outgrowth. Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system. Anna Fuller Fund Merck & Co., Inc. 2014-01-06T16:19:19Z 2014-01-06T16:19:19Z 2000-06 2000-04 Article http://purl.org/eprint/type/JournalArticle 08966273 1097-4199 http://hdl.handle.net/1721.1/83489 Zukerberg, Lawrence R, Gentry N Patrick, Margareta Nikolic, Sandrine Humbert, Chin-Lee Wu, Lorene M Lanier, Frank B Gertler, Marc Vidal, Richard A Van Etten, and Li-Huei Tsai. “Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth.” Neuron 26, no. 3 (June 2000): 633-646. Copyright © 2000 Cell Press https://orcid.org/0000-0003-3214-4554 en_US http://dx.doi.org/10.1016/S0896-6273(00)81200-3 Neuron Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier Open Archive |
| spellingShingle | Zukerberg, Lawrence R Patrick, Gentry N Nikolic, Margareta Humbert, Sandrine Wu, Chin-Lee Vidal, Marc Van Etten, Richard A Tsai, Li-Huei Lanier, Lorene M. Gertler, Frank Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth |
| title | Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth |
| title_full | Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth |
| title_fullStr | Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth |
| title_full_unstemmed | Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth |
| title_short | Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth |
| title_sort | cables links cdk5 and c abl and facilitates cdk5 tyrosine phosphorylation kinase upregulation and neurite outgrowth |
| url | http://hdl.handle.net/1721.1/83489 https://orcid.org/0000-0003-3214-4554 |
| work_keys_str_mv | AT zukerberglawrencer cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT patrickgentryn cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT nikolicmargareta cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT humbertsandrine cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT wuchinlee cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT vidalmarc cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT vanettenricharda cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT tsailihuei cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT lanierlorenem cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth AT gertlerfrank cableslinkscdk5andcablandfacilitatescdk5tyrosinephosphorylationkinaseupregulationandneuriteoutgrowth |