Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging
We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specifi...
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| Format: | Article |
| Language: | en_US |
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Royal Society of Chemistry, The
2014
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| Online Access: | http://hdl.handle.net/1721.1/83499 https://orcid.org/0000-0003-2220-4365 https://orcid.org/0000-0001-7188-8105 |
| _version_ | 1826190271644172288 |
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| author | Wei, He Chen, Ou Bawendi, Moungi G. Bruns, Oliver Thomas |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Wei, He Chen, Ou Bawendi, Moungi G. Bruns, Oliver Thomas |
| author_sort | Wei, He |
| collection | MIT |
| description | We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specific interactions with fetal bovine serum, the opportunity for specific labeling, and stability with respect to time, pH, and salinity. We report here on the magnetic characterization of ZDS-coated SPIONs and their in vitro and in vivo performance relative to non-specific interactions with HeLa cells and in mice, respectively. ZDS-coated SPIONs retained the superparamagnetism and saturation magnetization (M[subscript s]) of as-synthesized hydrophobic SPIONs, with M[subscript s] = 74 emu g[superscript −1] [Fe]. Moreover, ZDS-coated SPIONs showed only small non-specific uptake into HeLa cancer cells in vitro and low non-specific binding to serum proteins in vivo in mice. |
| first_indexed | 2024-09-23T08:37:42Z |
| format | Article |
| id | mit-1721.1/83499 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:37:42Z |
| publishDate | 2014 |
| publisher | Royal Society of Chemistry, The |
| record_format | dspace |
| spelling | mit-1721.1/834992022-09-30T10:03:31Z Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging Wei, He Chen, Ou Bawendi, Moungi G. Bruns, Oliver Thomas Massachusetts Institute of Technology. Department of Chemistry Wei, He Bruns, Oliver Thomas Chen, Ou Bawendi, Moungi G. We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specific interactions with fetal bovine serum, the opportunity for specific labeling, and stability with respect to time, pH, and salinity. We report here on the magnetic characterization of ZDS-coated SPIONs and their in vitro and in vivo performance relative to non-specific interactions with HeLa cells and in mice, respectively. ZDS-coated SPIONs retained the superparamagnetism and saturation magnetization (M[subscript s]) of as-synthesized hydrophobic SPIONs, with M[subscript s] = 74 emu g[superscript −1] [Fe]. Moreover, ZDS-coated SPIONs showed only small non-specific uptake into HeLa cancer cells in vitro and low non-specific binding to serum proteins in vivo in mice. National Institutes of Health (U.S.) (MIT-Harvard Center for Cancer Nanotechnology Excellence Grant 1U54-CA119349) National Cancer Institute (U.S.) (Grant R01-CA126642) Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (W911NF-07-D-0004) National Science Foundation (U.S.) (Collaborative Research in Chemistry Program CHE-0714189) 2014-01-06T17:30:09Z 2014-01-06T17:30:09Z 2012-10 2012-06 Article http://purl.org/eprint/type/JournalArticle 1757-9694 1757-9708 http://hdl.handle.net/1721.1/83499 Wei, He, Oliver T. Bruns, Ou Chen, and Moungi G. Bawendi. “Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging.” Integrative Biology 5, no. 1 (2012): 108. https://orcid.org/0000-0003-2220-4365 https://orcid.org/0000-0001-7188-8105 en_US http://dx.doi.org/10.1039/c2ib20142a Integrative Biology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Royal Society of Chemistry, The PMC |
| spellingShingle | Wei, He Chen, Ou Bawendi, Moungi G. Bruns, Oliver Thomas Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging |
| title | Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging |
| title_full | Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging |
| title_fullStr | Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging |
| title_full_unstemmed | Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging |
| title_short | Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging |
| title_sort | compact zwitterion coated iron oxide nanoparticles for in vitro and in vivo imaging |
| url | http://hdl.handle.net/1721.1/83499 https://orcid.org/0000-0003-2220-4365 https://orcid.org/0000-0001-7188-8105 |
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