Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism
Reading about another person’s beliefs engages ‘Theory of Mind’ processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing i...
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2014
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| Online Access: | http://hdl.handle.net/1721.1/83518 https://orcid.org/0000-0003-2377-1791 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1811087218625740800 |
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| author | Dufour, Nicholas Paul Redcay, Elizabeth Young, Liane Moran, Joseph M. Triantafyllou, Christina Gabrieli, John D. E. Rushton, Penelope Mavros Saxe, Rebecca R. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Dufour, Nicholas Paul Redcay, Elizabeth Young, Liane Moran, Joseph M. Triantafyllou, Christina Gabrieli, John D. E. Rushton, Penelope Mavros Saxe, Rebecca R. |
| author_sort | Dufour, Nicholas Paul |
| collection | MIT |
| description | Reading about another person’s beliefs engages ‘Theory of Mind’ processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing in a very large sample of neurotypical (N = 462) individuals, and a group of high-functioning individuals with autism spectrum disorders (N = 31), using both region-of-interest and whole-brain analyses. This large sample allowed us to investigate group differences in brain activation to Theory of Mind tasks with unusually high sensitivity. There were no differences between neurotypical participants and those diagnosed with autism spectrum disorder. These results imply that the social cognitive impairments typical of autism spectrum disorder can occur without measurable changes in the size, location or response magnitude of activity during explicit Theory of Mind tasks administered to adults. |
| first_indexed | 2024-09-23T13:41:57Z |
| format | Article |
| id | mit-1721.1/83518 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:41:57Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/835182022-10-01T16:34:40Z Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism Dufour, Nicholas Paul Redcay, Elizabeth Young, Liane Moran, Joseph M. Triantafyllou, Christina Gabrieli, John D. E. Rushton, Penelope Mavros Saxe, Rebecca R. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Dufour, Nicholas Paul Rushton, Penelope Mavros Triantafyllou, Christina Gabrieli, John D. E. Saxe, Rebecca R. Reading about another person’s beliefs engages ‘Theory of Mind’ processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing in a very large sample of neurotypical (N = 462) individuals, and a group of high-functioning individuals with autism spectrum disorders (N = 31), using both region-of-interest and whole-brain analyses. This large sample allowed us to investigate group differences in brain activation to Theory of Mind tasks with unusually high sensitivity. There were no differences between neurotypical participants and those diagnosed with autism spectrum disorder. These results imply that the social cognitive impairments typical of autism spectrum disorder can occur without measurable changes in the size, location or response magnitude of activity during explicit Theory of Mind tasks administered to adults. Simons Foundation National Science Foundation (U.S.) (Grant 095518) Charles A. Dana Foundation National Science Foundation (U.S.). Graduate Research Fellowship Program (Grant 0645960) John Merck Scholars Program (Grant) 2014-01-06T19:51:05Z 2014-01-06T19:51:05Z 2013-09 2013-01 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/83518 Dufour, Nicholas, Elizabeth Redcay, Liane Young, Penelope L. Mavros, Joseph M. Moran, Christina Triantafyllou, John D. E. Gabrieli, and Rebecca Saxe. “Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism.” Edited by Sam Gilbert. PLoS ONE 8, no. 9 (September 20, 2013): e75468. https://orcid.org/0000-0003-2377-1791 https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1371/journal.pone.0075468 PLoS ONE http://creativecommons.org/licenses/by/2.5/ application/pdf Public Library of Science PLoS |
| spellingShingle | Dufour, Nicholas Paul Redcay, Elizabeth Young, Liane Moran, Joseph M. Triantafyllou, Christina Gabrieli, John D. E. Rushton, Penelope Mavros Saxe, Rebecca R. Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism |
| title | Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism |
| title_full | Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism |
| title_fullStr | Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism |
| title_full_unstemmed | Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism |
| title_short | Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism |
| title_sort | similar brain activation during false belief tasks in a large sample of adults with and without autism |
| url | http://hdl.handle.net/1721.1/83518 https://orcid.org/0000-0003-2377-1791 https://orcid.org/0000-0003-1158-5692 |
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