MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes
The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the reciprocal relationship—that of the cell cycle controlling the miR-16 family....
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| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2014
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| Online Access: | http://hdl.handle.net/1721.1/83616 https://orcid.org/0000-0002-3872-2856 |
| _version_ | 1811082780946202624 |
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| author | Rissland, Olivia S. Hong, Sue-Jean Bartel, David Rissland, Olivia S. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Rissland, Olivia S. Hong, Sue-Jean Bartel, David Rissland, Olivia S. |
| author_sort | Rissland, Olivia S. |
| collection | MIT |
| description | The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the reciprocal relationship—that of the cell cycle controlling the miR-16 family. Levels of this family increase rapidly as cells are arrested in G0. Conversely, as cells are released from G0 arrest, levels of the miR-16 family rapidly decrease. Such rapid changes are made possible by the unusual instabilities of several family members. The repression mediated by the miR-16 family is sensitive to these cell-cycle changes, which suggests that the rapid upregulation of the miR-16 family reinforces cell-cycle arrest in G0. Upon cell-cycle re-entry, the rapid decay of several members allows levels of the family to decrease, alleviating repression of target genes and allowing proper resumption of the cell cycle. |
| first_indexed | 2024-09-23T12:08:53Z |
| format | Article |
| id | mit-1721.1/83616 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:08:53Z |
| publishDate | 2014 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/836162022-09-28T00:30:45Z MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes Rissland, Olivia S. Hong, Sue-Jean Bartel, David Rissland, Olivia S. Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Rissland, Olivia S. Hong, Sue-Jean Bartel, David The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the reciprocal relationship—that of the cell cycle controlling the miR-16 family. Levels of this family increase rapidly as cells are arrested in G0. Conversely, as cells are released from G0 arrest, levels of the miR-16 family rapidly decrease. Such rapid changes are made possible by the unusual instabilities of several family members. The repression mediated by the miR-16 family is sensitive to these cell-cycle changes, which suggests that the rapid upregulation of the miR-16 family reinforces cell-cycle arrest in G0. Upon cell-cycle re-entry, the rapid decay of several members allows levels of the family to decrease, alleviating repression of target genes and allowing proper resumption of the cell cycle. National Institutes of Health (U.S.) (grant GM06703) National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award (GM0888)) Canadian Institutes of Health Research 2014-01-08T21:15:36Z 2014-01-08T21:15:36Z 2011-09 2011-07 Article http://purl.org/eprint/type/JournalArticle 10972765 1097-4172 http://hdl.handle.net/1721.1/83616 Rissland, Olivia S., Sue-Jean Hong, and David P. Bartel. “MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes.” Molecular Cell 43, no. 6 (September 2011): 993-1004.© 2011 Elsevier Inc. https://orcid.org/0000-0002-3872-2856 en_US http://dx.doi.org/10.1016/j.molcel.2011.08.021 Molecular Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier B.V. Elsevier Open Archive |
| spellingShingle | Rissland, Olivia S. Hong, Sue-Jean Bartel, David Rissland, Olivia S. MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes |
| title | MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes |
| title_full | MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes |
| title_fullStr | MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes |
| title_full_unstemmed | MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes |
| title_short | MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes |
| title_sort | microrna destabilization enables dynamic regulation of the mir 16 family in response to cell cycle changes |
| url | http://hdl.handle.net/1721.1/83616 https://orcid.org/0000-0002-3872-2856 |
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