Analysis and design of RNA sequencing experiments for identifying isoform regulation
Through alternative splicing, most human genes express multiple isoforms that often differ in function. To infer isoform regulation from high-throughput sequencing of cDNA fragments (RNA-seq), we developed the mixture-of-isoforms (MISO) model, a statistical model that estimates expression of alterna...
| Hauptverfasser: | , , , |
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| Format: | Artikel |
| Sprache: | en_US |
| Veröffentlicht: |
Nature Publishing Group
2014
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| Online Zugang: | http://hdl.handle.net/1721.1/83628 |