Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin
Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian wound healing process is poorly understood. We discover that supplementing...
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2014
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| Online Access: | http://hdl.handle.net/1721.1/83861 https://orcid.org/0000-0001-8294-9364 https://orcid.org/0000-0002-8033-8380 |
| _version_ | 1811071384452857856 |
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| author | Poutahidis, Theofilos Levkovich, Tatiana Qi, Peimin Chatzigiagkos, Antonis Alm, Eric J. Erdman, Susan E. Kearney, Sean Michael Varian, Bernard Lakritz, Jessica Ibrahim, Yassin |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Poutahidis, Theofilos Levkovich, Tatiana Qi, Peimin Chatzigiagkos, Antonis Alm, Eric J. Erdman, Susan E. Kearney, Sean Michael Varian, Bernard Lakritz, Jessica Ibrahim, Yassin |
| author_sort | Poutahidis, Theofilos |
| collection | MIT |
| description | Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian wound healing process is poorly understood. We discover that supplementing the gut microbiome with lactic acid microbes in drinking water accelerates the wound-healing process to occur in half the time required for matched control animals. Further, we find that Lactobacillus reuteri enhances wound-healing properties through up-regulation of the neuropeptide hormone oxytocin, a factor integral in social bonding and reproduction, by a vagus nerve-mediated pathway. Bacteria-triggered oxytocin serves to activate host CD4+Foxp3+CD25+ immune T regulatory cells conveying transplantable wound healing capacity to naive Rag2-deficient animals. This study determined oxytocin to be a novel component of a multi-directional gut microbe-brain-immune axis, with wound-healing capability as a previously unrecognized output of this axis. We also provide experimental evidence to support long-standing medical traditions associating diet, social practices, and the immune system with efficient recovery after injury, sustained good health, and longevity. |
| first_indexed | 2024-09-23T08:50:14Z |
| format | Article |
| id | mit-1721.1/83861 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:50:14Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/838612022-09-23T14:51:16Z Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin Poutahidis, Theofilos Levkovich, Tatiana Qi, Peimin Chatzigiagkos, Antonis Alm, Eric J. Erdman, Susan E. Kearney, Sean Michael Varian, Bernard Lakritz, Jessica Ibrahim, Yassin Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Kearney, Sean Michael Qi, Peimin Varian, Bernard Lakritz, Jessica Ibrahim, Yassin Alm, Eric J. Erdman, Susan E. Poutahidis, Theofilos Levkovich, Tatiana Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian wound healing process is poorly understood. We discover that supplementing the gut microbiome with lactic acid microbes in drinking water accelerates the wound-healing process to occur in half the time required for matched control animals. Further, we find that Lactobacillus reuteri enhances wound-healing properties through up-regulation of the neuropeptide hormone oxytocin, a factor integral in social bonding and reproduction, by a vagus nerve-mediated pathway. Bacteria-triggered oxytocin serves to activate host CD4+Foxp3+CD25+ immune T regulatory cells conveying transplantable wound healing capacity to naive Rag2-deficient animals. This study determined oxytocin to be a novel component of a multi-directional gut microbe-brain-immune axis, with wound-healing capability as a previously unrecognized output of this axis. We also provide experimental evidence to support long-standing medical traditions associating diet, social practices, and the immune system with efficient recovery after injury, sustained good health, and longevity. National Institutes of Health (U.S.) (Grant P30-ES002109) National Institutes of Health (U.S.) (Grant U01 CA164337) National Institutes of Health (U.S.) (Grant R01CA08854) 2014-01-10T17:18:43Z 2014-01-10T17:18:43Z 2013-10 2013-04 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/83861 Poutahidis, Theofilos, Sean M. Kearney, Tatiana Levkovich, Peimin Qi, Bernard J. Varian, Jessica R. Lakritz, Yassin M. Ibrahim, Antonis Chatzigiagkos, Eric J. Alm, and Susan E. Erdman. “Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin.” Edited by Silvana Gaetani. PLoS ONE 8, no. 10 (October 30, 2013): e78898. https://orcid.org/0000-0001-8294-9364 https://orcid.org/0000-0002-8033-8380 en_US http://dx.doi.org/10.1371/journal.pone.0078898 PLoS ONE http://creativecommons.org/licenses/by/2.5/ application/pdf Public Library of Science PLoS |
| spellingShingle | Poutahidis, Theofilos Levkovich, Tatiana Qi, Peimin Chatzigiagkos, Antonis Alm, Eric J. Erdman, Susan E. Kearney, Sean Michael Varian, Bernard Lakritz, Jessica Ibrahim, Yassin Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin |
| title | Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin |
| title_full | Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin |
| title_fullStr | Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin |
| title_full_unstemmed | Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin |
| title_short | Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin |
| title_sort | microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin |
| url | http://hdl.handle.net/1721.1/83861 https://orcid.org/0000-0001-8294-9364 https://orcid.org/0000-0002-8033-8380 |
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