T-cell death following immune activation is mediated by mitochondria-localized SARM
Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile α- and heat armadillo-motif-containing protein (SARM), the most conserved Toll-like receptors adaptor, is p...
Main Authors: | Panneerselvam, P., Singh, L. P., Selvarajan, V., Chng, W. J., Ng, S. B., Tan, N. S., Ho, B., Ding, Jeak Ling, Chen, Jianzhu |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2014
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Online Access: | http://hdl.handle.net/1721.1/84108 https://orcid.org/0000-0002-5687-6154 |
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