Cell-type specific cholinergic modulation of the cortex
Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2013.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2014
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| Online Access: | http://hdl.handle.net/1721.1/84383 |
| _version_ | 1826210950642925568 |
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| author | Chen, Naiyan |
| author2 | Mriganka Sur. |
| author_facet | Mriganka Sur. Chen, Naiyan |
| author_sort | Chen, Naiyan |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2013. |
| first_indexed | 2024-09-23T14:58:01Z |
| format | Thesis |
| id | mit-1721.1/84383 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:58:01Z |
| publishDate | 2014 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/843832019-04-11T11:01:45Z Cell-type specific cholinergic modulation of the cortex Chen, Naiyan Mriganka Sur. Massachusetts Institute of Technology. Computational and Systems Biology Program. Massachusetts Institute of Technology. Computational and Systems Biology Program. Computational and Systems Biology Program. Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2013. Cataloged from PDF version of thesis. "September 2013." Page 126 blank. Includes bibliographical references. The cholinergic innervation of the neocortex by afferent fibers originating in the nucleus basalis (NB) of the basal forebrain is implicated in modulating diverse neocortical functions including information processing, cortical plasticity, arousal and attention. To understand the physiological basis of these brain functions during cholinergic modulation, it is critical to identify the cortical circuit elements involved and define how their interactions contribute to cortical network dynamics. In this thesis, I present evidence showing how specific neuronal and glial cell types can be differentially modulated by acetylcholine (Ach), resulting in dynamic functional interactions during ACh-modulated information processing and cortical plasticity. Chapter 2 identifies somatostatin-expressing neurons as a dominant player in driving decorrelation and information processing through its intimate interactions with parvalbumin-expressing and pyramidal neurons. Chapter 3 highlights astrocytes and their interactions with pyramidal neurons as important drives for stimulus-specific cortical plasticity during cholinergic modulation. This is one of the earliest works that has mapped the functional role of distinct cell-types and their interactions to specific brain functions modulated by ACh, thereby setting the foundation for future studies to manipulate these specific functional interactions in both normal and diseased brains. by Naiyan Chen. Ph.D. 2014-01-23T18:40:26Z 2014-01-23T18:40:26Z 2013 Thesis http://hdl.handle.net/1721.1/84383 867639633 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 126 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Computational and Systems Biology Program. Chen, Naiyan Cell-type specific cholinergic modulation of the cortex |
| title | Cell-type specific cholinergic modulation of the cortex |
| title_full | Cell-type specific cholinergic modulation of the cortex |
| title_fullStr | Cell-type specific cholinergic modulation of the cortex |
| title_full_unstemmed | Cell-type specific cholinergic modulation of the cortex |
| title_short | Cell-type specific cholinergic modulation of the cortex |
| title_sort | cell type specific cholinergic modulation of the cortex |
| topic | Computational and Systems Biology Program. |
| url | http://hdl.handle.net/1721.1/84383 |
| work_keys_str_mv | AT chennaiyan celltypespecificcholinergicmodulationofthecortex |